GO Annotations Graph

• Symbol: Ppp3ca
• Name: protein phosphatase 3, catalytic subunit, alpha isoform
• ID: MGI:107164

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	ISO	J:155856
Molecular Function	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	TAS	Reactome:R-MMU-2025936
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IDA	J:257321
Molecular Function	GO:0005516	calmodulin binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	IBA	J:265628
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	ISO	J:155856
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	ISO	J:164563
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	IDA	J:257321
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	IBA	J:265628
Molecular Function	GO:0016018	cyclosporin A binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0017018	myosin phosphatase activity	IEA	J:72245
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	ISO	J:155856
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	IDA	J:100019
Molecular Function	GO:0005515	protein binding	IPI	J:282598
Molecular Function	GO:0005515	protein binding	IPI	J:319680
Molecular Function	GO:0005515	protein binding	IPI	J:257321
Molecular Function	GO:0005515	protein binding	IPI	J:183831
Molecular Function	GO:0005515	protein binding	IPI	J:163320
Molecular Function	GO:0005515	protein binding	IPI	J:259128
Molecular Function	GO:0005515	protein binding	IPI	J:174325
Molecular Function	GO:0005515	protein binding	IPI	J:126237
Molecular Function	GO:0005515	protein binding	IPI	J:81920
Molecular Function	GO:0005515	protein binding	IPI	J:116445
Molecular Function	GO:0005515	protein binding	IPI	J:142163
Molecular Function	GO:0005515	protein binding	IPI	J:150410
Molecular Function	GO:0005515	protein binding	IPI	J:126237
Molecular Function	GO:0005515	protein binding	IPI	J:96468
Molecular Function	GO:0005515	protein binding	IPI	J:81920
Molecular Function	GO:0005515	protein binding	IPI	J:81920
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:164563
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	ISO	J:155856
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0005955	calcineurin complex	IDA	J:257321
Cellular Component	GO:0005955	calcineurin complex	ISO	J:164563
Cellular Component	GO:0005955	calcineurin complex	ISO	J:155856
Cellular Component	GO:0005955	calcineurin complex	NAS	J:320122
Cellular Component	GO:0005955	calcineurin complex	IBA	J:265628
Cellular Component	GO:0005955	calcineurin complex	IDA	J:126237
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:320150
Cellular Component	GO:0005737	cytoplasm	IDA	J:103832
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	NAS	J:320049
Cellular Component	GO:0005829	cytosol	NAS	J:319677
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2025936
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:126237
Cellular Component	GO:0043197	dendritic spine	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:130656
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:130656
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	IDA	J:126237
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:126237
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	IMP	J:130656
Cellular Component	GO:0008287	protein serine/threonine phosphatase complex	NAS	J:320050
Cellular Component	GO:0008287	protein serine/threonine phosphatase complex	NAS	J:320049
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:130656
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:130656
Cellular Component	GO:0036057	slit diaphragm	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0030018	Z disc	IDA	J:96468
Biological Process	GO:0097720	calcineurin-mediated signaling	ISO	J:164563
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	ISO	J:164563
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IBA	J:265628
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IDA	J:38327
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IGI	J:142475
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IDA	J:174325
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IMP	J:46399
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IGI	J:142475
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IMP	J:46398
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IDA	J:147774
Biological Process	GO:0006816	calcium ion transport	IMP	J:84257
Biological Process	GO:0019722	calcium-mediated signaling	IGI	J:150410
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	IGI	J:79608
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0048813	dendrite morphogenesis	IMP	J:194263
Biological Process	GO:0016311	dephosphorylation	IDA	J:100019
Biological Process	GO:0016311	dephosphorylation	IDA	J:81920
Biological Process	GO:0008544	epidermis development	IMP	J:159586
Biological Process	GO:0060079	excitatory postsynaptic potential	IGI	J:120963
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IMP	J:84257
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:159586
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:54583
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:96807
Biological Process	GO:0033555	multicellular organismal response to stress	IDA	J:73985
Biological Process	GO:1905949	negative regulation of calcium ion import across plasma membrane	NAS	J:319981
Biological Process	GO:0035562	negative regulation of chromatin binding	IMP	J:194263
Biological Process	GO:0050774	negative regulation of dendrite morphogenesis	IMP	J:194263
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:208305
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:208305
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0023057	negative regulation of signaling	IMP	J:319680
Biological Process	GO:1901386	negative regulation of voltage-gated calcium channel activity	NAS	J:319981
Biological Process	GO:0070262	peptidyl-serine dephosphorylation	ISO	J:164563
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IMP	J:71750
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	NAS	J:320049
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	NAS	J:319999
Biological Process	GO:1905665	positive regulation of calcium ion import across plasma membrane	NAS	J:319981
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	IGI	J:208305
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	IGI	J:233562
Biological Process	GO:1903244	positive regulation of cardiac muscle hypertrophy in response to stress	IDA	J:149624
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:1905205	positive regulation of connective tissue replacement	IGI	J:233562
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA	J:197653
Biological Process	GO:0045807	positive regulation of endocytosis	IMP	J:242470
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:208305
Biological Process	GO:0090193	positive regulation of glomerulus development	IMP	J:93625
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IMP	J:103832
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IMP	J:320150
Biological Process	GO:0046878	positive regulation of saliva secretion	IMP	J:169854
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:208305
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:215013
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121907
Biological Process	GO:1901387	positive regulation of voltage-gated calcium channel activity	NAS	J:319981
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:130656
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IMP	J:130656
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:130656
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IMP	J:130656
Biological Process	GO:0006470	protein dephosphorylation	IDA	J:257321
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:155856
Biological Process	GO:0006470	protein dephosphorylation	IMP	J:150410
Biological Process	GO:0006470	protein dephosphorylation	IMP	J:288625
Biological Process	GO:0006606	protein import into nucleus	IMP	J:288625
Biological Process	GO:0006606	protein import into nucleus	IDA	J:73985
Biological Process	GO:0061006	regulation of cell proliferation involved in kidney morphogenesis	IMP	J:93625
Biological Process	GO:0097205	renal filtration	IMP	J:110350
Biological Process	GO:0051592	response to calcium ion	ISO	J:164563
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:110822
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:100019
Biological Process	GO:0014883	transition between fast and slow fiber	IDA	J:174325