GO Annotations Graph

• Symbol: Ptpn22
• Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
• ID: MGI:107170

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0019900	kinase binding	IPI	J:169817
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	IBA	J:265628
Molecular Function	GO:0016791	phosphatase activity	ISO	J:164563
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:180575
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IDA	J:234957
Molecular Function	GO:0017124	SH3 domain binding	IPI	J:169817
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:169808
Cellular Component	GO:0005737	cytoplasm	IDA	J:169817
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	IDA	J:169808
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:169808
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0071225	cellular response to muramyl dipeptide	ISO	J:164563
Biological Process	GO:0071225	cellular response to muramyl dipeptide	IDA	J:221551
Biological Process	GO:0016311	dephosphorylation	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:221551
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:208241
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:221551
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032717	negative regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0032717	negative regulation of interleukin-8 production	IMP	J:221551
Biological Process	GO:0043508	negative regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP	J:221551
Biological Process	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO	J:164563
Biological Process	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IBA	J:265628
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	IMP	J:221551
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	IBA	J:265628
Biological Process	GO:0050868	negative regulation of T cell activation	ISO	J:164563
Biological Process	GO:0050868	negative regulation of T cell activation	IMP	J:170289
Biological Process	GO:0050868	negative regulation of T cell activation	IBA	J:265628
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:221551
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IBA	J:265628
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	IBA	J:265628
Biological Process	GO:0035644	phosphoanandamide dephosphorylation	IDA	J:169898
Biological Process	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation	IMP	J:208241
Biological Process	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation	IBA	J:265628
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IMP	J:208241
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:221551
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:221551
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:208241
Biological Process	GO:0071663	positive regulation of granzyme B production	IMP	J:208241
Biological Process	GO:0071663	positive regulation of granzyme B production	IBA	J:265628
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IMP	J:208241
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:208241
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IDA	J:234957
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IMP	J:208241
Biological Process	GO:1902523	positive regulation of protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:1902523	positive regulation of protein K63-linked ubiquitination	IMP	J:208241
Biological Process	GO:1902523	positive regulation of protein K63-linked ubiquitination	IBA	J:265628
Biological Process	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	ISO	J:164563
Biological Process	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	IMP	J:208241
Biological Process	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	IBA	J:265628
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	IMP	J:208241
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	IBA	J:265628
Biological Process	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	IMP	J:208241
Biological Process	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	IBA	J:265628
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	IMP	J:208241
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	IBA	J:265628
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	IMP	J:32702
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	IMP	J:90029
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0002685	regulation of leukocyte migration	IMP	J:208241
Biological Process	GO:0032817	regulation of natural killer cell proliferation	ISO	J:164563
Biological Process	GO:1901222	regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1901222	regulation of NIK/NF-kappaB signaling	IMP	J:221551
Biological Process	GO:1901222	regulation of NIK/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0050856	regulation of T cell receptor signaling pathway	IEA	J:72247
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0030217	T cell differentiation	IBA	J:265628
Biological Process	GO:0030217	T cell differentiation	IMP	J:90029
Biological Process	GO:0050852	T cell receptor signaling pathway	IBA	J:265628
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:90029