Ppp3r1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
MGI:107172

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity	IBA	J:265628
Molecular Function	GO:0016018	cyclosporin A binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	IPI	J:163320
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0019902	phosphatase binding	IPI	J:257321
Molecular Function	GO:0019902	phosphatase binding	IBA	J:265628
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	ISO	J:155856
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	IMP	J:70266
Molecular Function	GO:0005515	protein binding	IPI	J:163320
Molecular Function	GO:0005515	protein binding	IPI	J:109068
Molecular Function	GO:0005515	protein binding	IPI	J:163320
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Cellular Component	GO:0005955	calcineurin complex	NAS	J:320122
Cellular Component	GO:0005955	calcineurin complex	IDA	J:257321
Cellular Component	GO:0005955	calcineurin complex	ISO	J:164563
Cellular Component	GO:0005955	calcineurin complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	NAS	J:320049
Cellular Component	GO:0005829	cytosol	NAS	J:319677
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2025936
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:73203
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:73203
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:206458
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:206458
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:199633
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:199633
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:199633
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:199633
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:199633
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IMP	J:199633
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	IMP	J:166629
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	IDA	J:166629
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0098794	postsynapse	IDA	J:166629
Cellular Component	GO:0008287	protein serine/threonine phosphatase complex	NAS	J:320049
Cellular Component	GO:0008287	protein serine/threonine phosphatase complex	NAS	J:320050
Cellular Component	GO:0042383	sarcolemma	IDA	J:163320
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:73203
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:73203
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:73203
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:73203
Cellular Component	GO:0045202	synapse	EXP	J:206458
Cellular Component	GO:0045202	synapse	IDA	J:206458
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:70266
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:70266
Biological Process	GO:0097720	calcineurin-mediated signaling	IBA	J:265628
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	ISO	J:164563
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IGI	J:144171
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IGI	J:144171
Biological Process	GO:0001837	epithelial to mesenchymal transition	IMP	J:92515
Biological Process	GO:0007507	heart development	IMP	J:92515
Biological Process	GO:0007507	heart development	IMP	J:92515
Biological Process	GO:0060487	lung epithelial cell differentiation	IMP	J:114501
Biological Process	GO:0022011	myelination in peripheral nervous system	IMP	J:144171
Biological Process	GO:1905949	negative regulation of calcium ion import across plasma membrane	NAS	J:319981
Biological Process	GO:1901386	negative regulation of voltage-gated calcium channel activity	NAS	J:319981
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	NAS	J:319999
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	NAS	J:320049
Biological Process	GO:1905665	positive regulation of calcium ion import across plasma membrane	NAS	J:319981
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:1901387	positive regulation of voltage-gated calcium channel activity	NAS	J:319981
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:73203
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IMP	J:73203
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:166629
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IMP	J:166629
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:155856
Biological Process	GO:0006470	protein dephosphorylation	IBA	J:265628
Biological Process	GO:0006470	protein dephosphorylation	IMP	J:70266
Biological Process	GO:0006606	protein import into nucleus	IMP	J:70266
Biological Process	GO:0034504	protein localization to nucleus	IMP	J:114501
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IMP	J:73203
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IMP	J:73203
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IDA	J:73203
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IDA	J:73203
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	IMP	J:199633
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	IMP	J:199633
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	IDA	J:199633
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	IDA	J:199633
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	IDA	J:199633
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	IMP	J:199633
Biological Process	GO:0014044	Schwann cell development	IMP	J:144171

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24