GO Annotations Graph

• Symbol: Serpinf2
• Name: serine (or cysteine) peptidase inhibitor, clade F, member 2
• ID: MGI:107173

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030414	peptidase inhibitor activity	IEA	J:60000
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:155856
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005577	fibrinogen complex	ISO	J:164563
Biological Process	GO:0006953	acute-phase response	IEA	J:60000
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:160044
Biological Process	GO:0030199	collagen fibril organization	IMP	J:180461
Biological Process	GO:0002034	maintenance of blood vessel diameter homeostasis by renin-angiotensin	IMP	J:160044
Biological Process	GO:0010951	negative regulation of endopeptidase activity	IBA	J:265628
Biological Process	GO:0051918	negative regulation of fibrinolysis	ISO	J:155856
Biological Process	GO:0051918	negative regulation of fibrinolysis	ISO	J:164563
Biological Process	GO:0010466	negative regulation of peptidase activity	IEA	J:60000
Biological Process	GO:0010757	negative regulation of plasminogen activation	ISO	J:164563
Biological Process	GO:0045597	positive regulation of cell differentiation	ISO	J:164563
Biological Process	GO:0045597	positive regulation of cell differentiation	IMP	J:156479
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	IMP	J:160044
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	IMP	J:160044
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:180461
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	IMP	J:180461
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	ISO	J:164563