Atm GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Atm
ataxia telangiectasia mutated
MGI:107202

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0004677	DNA-dependent protein kinase activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:96923
Molecular Function	GO:0004672	protein kinase activity	IDA	J:92518
Molecular Function	GO:0004672	protein kinase activity	TAS	J:94951
Molecular Function	GO:0004672	protein kinase activity	IDA	J:60946
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005813	centrosome	IDA	J:306588
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:268784
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:1990391	DNA repair complex	ISO	J:208295
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912421
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912431
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912462
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912487
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:268784
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	TAS	J:94951
Cellular Component	GO:0005782	peroxisomal matrix	ISO	J:164563
Cellular Component	GO:0005777	peroxisome	IEA	J:60000
Cellular Component	GO:0005819	spindle	IDA	J:93217
Biological Process	GO:0007420	brain development	IGI	J:108789
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0071480	cellular response to gamma radiation	ISO	J:164563
Biological Process	GO:0071500	cellular response to nitrosative stress	ISO	J:164563
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0071300	cellular response to retinoic acid	IMP	J:165661
Biological Process	GO:0071481	cellular response to X-ray	ISO	J:164563
Biological Process	GO:0070192	chromosome organization involved in meiotic cell cycle	IMP	J:35914
Biological Process	GO:0008340	determination of adult lifespan	IGI	J:146070
Biological Process	GO:0008340	determination of adult lifespan	IGI	J:146070
Biological Process	GO:0000077	DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0000077	DNA damage checkpoint signaling	IBA	J:265628
Biological Process	GO:0000077	DNA damage checkpoint signaling	IMP	J:86382
Biological Process	GO:0006974	DNA damage response	ISO	J:155856
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IGI	J:146070
Biological Process	GO:0006974	DNA damage response	IGI	J:146070
Biological Process	GO:0006974	DNA damage response	TAS	J:65540
Biological Process	GO:0006974	DNA damage response	ISO	J:206795
Biological Process	GO:0006281	DNA repair	IMP	J:73636
Biological Process	GO:0006281	DNA repair	IDA	J:92518
Biological Process	GO:0006281	DNA repair	IMP	J:94088
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IMP	J:146070
Biological Process	GO:0097695	establishment of protein-containing complex localization to telomere	ISO	J:164563
Biological Process	GO:0097694	establishment of RNA localization to telomere	ISO	J:164563
Biological Process	GO:0007292	female gamete generation	IMP	J:96250
Biological Process	GO:0008585	female gonad development	IMP	J:35914
Biological Process	GO:0007143	female meiotic nuclear division	IMP	J:35914
Biological Process	GO:0007507	heart development	IGI	J:108789
Biological Process	GO:0071044	histone mRNA catabolic process	ISO	J:164563
Biological Process	GO:0002376	immune system process	IMP	J:35914
Biological Process	GO:0002377	immunoglobulin production	IMP	J:35914
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IBA	J:265628
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IGI	J:122559
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:111068
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:65540
Biological Process	GO:0042159	lipoprotein catabolic process	IGI	J:100500
Biological Process	GO:0007140	male meiotic nuclear division	IMP	J:35914
Biological Process	GO:0045141	meiotic telomere clustering	IMP	J:147391
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0007094	mitotic spindle assembly checkpoint signaling	ISO	J:164563
Biological Process	GO:0035264	multicellular organism growth	IMP	J:35914
Biological Process	GO:0030889	negative regulation of B cell proliferation	ISO	J:164563
Biological Process	GO:1904354	negative regulation of telomere capping	ISO	J:164563
Biological Process	GO:1904262	negative regulation of TORC1 signaling	ISO	J:164563
Biological Process	GO:1904262	negative regulation of TORC1 signaling	IMP	J:200700
Biological Process	GO:1904262	negative regulation of TORC1 signaling	IBA	J:265628
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:59934
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:68074
Biological Process	GO:0048599	oocyte development	IMP	J:115619
Biological Process	GO:0001541	ovarian follicle development	IMP	J:35914
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	ISO	J:206795
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0000425	pexophagy	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	IMP	J:165661
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:1903626	positive regulation of DNA catabolic process	ISO	J:155856
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	IGI	J:59934
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	IGI	J:111068
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	IGI	J:59934
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:1904884	positive regulation of telomerase catalytic core complex assembly	ISO	J:164563
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	IMP	J:228143
Biological Process	GO:1904358	positive regulation of telomere maintenance via telomere lengthening	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:165661
Biological Process	GO:0009791	post-embryonic development	IMP	J:35914
Biological Process	GO:0002331	pre-B cell allelic exclusion	IMP	J:149451
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:92518
Biological Process	GO:0010506	regulation of autophagy	IMP	J:200700
Biological Process	GO:0010506	regulation of autophagy	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:155856
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:1905843	regulation of cellular response to gamma radiation	ISO	J:155856
Biological Process	GO:1903978	regulation of microglial cell activation	ISO	J:155856
Biological Process	GO:0032210	regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0090399	replicative senescence	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0010212	response to ionizing radiation	ISO	J:164563
Biological Process	GO:0010212	response to ionizing radiation	IGI	J:146070
Biological Process	GO:0010212	response to ionizing radiation	IGI	J:59934
Biological Process	GO:0010212	response to ionizing radiation	IGI	J:146070
Biological Process	GO:0042770	signal transduction in response to DNA damage	ISO	J:164563
Biological Process	GO:0001756	somitogenesis	IGI	J:108789
Biological Process	GO:0000723	telomere maintenance	IBA	J:265628
Biological Process	GO:0048538	thymus development	IMP	J:35914
Biological Process	GO:0033151	V(D)J recombination	IGI	J:204750

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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