GO Annotations Graph

• Symbol: Ctss
• Name: cathepsin S
• ID: MGI:107341

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005518	collagen binding	ISO	J:164563
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	IBA	J:265628
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	EXP	J:93590
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	ISO	J:155856
Molecular Function	GO:0001968	fibronectin binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0043236	laminin binding	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IDA	J:88531
Molecular Function	GO:0043394	proteoglycan binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0031905	early endosome lumen	TAS	Reactome:R-NUL-1236960
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IBA	J:265628
Cellular Component	GO:0005764	lysosome	IDA	J:261411
Cellular Component	GO:0005764	lysosome	IDA	J:88531
Cellular Component	GO:0016020	membrane	IDA	J:88531
Cellular Component	GO:0045335	phagocytic vesicle	ISO	J:164563
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	ISO	J:164563
Biological Process	GO:0048002	antigen processing and presentation of peptide antigen	ISO	J:164563
Biological Process	GO:0034769	basement membrane disassembly	IMP	J:206911
Biological Process	GO:0034769	basement membrane disassembly	ISO	J:164563
Biological Process	GO:0045453	bone resorption	ISO	J:155856
Biological Process	GO:0030574	collagen catabolic process	ISO	J:164563
Biological Process	GO:0006955	immune response	IBA	J:265628
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:2001259	positive regulation of cation channel activity	ISO	J:164563
Biological Process	GO:2001259	positive regulation of cation channel activity	IDA	J:219065
Biological Process	GO:0050729	positive regulation of inflammatory response	IGI	J:78331
Biological Process	GO:0010952	positive regulation of peptidase activity	IBA	J:265628
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IDA	J:88531
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	IMP	J:206911
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	IBA	J:265628
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0010447	response to acidic pH	ISO	J:164563