GO Annotations Graph

• Symbol: Il17a
• Name: interleukin 17A
• ID: MGI:107364

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IDA	J:242717
Molecular Function	GO:0005515	protein binding	IPI	J:155093
Molecular Function	GO:0046982	protein heterodimerization activity	IDA	J:155093
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:155093
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:165738
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141227
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:190936
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:157744
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:155093
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:242717
Cellular Component	GO:0005615	extracellular space	IDA	J:153850
Cellular Component	GO:0005615	extracellular space	IDA	J:104231
Cellular Component	GO:0005615	extracellular space	IDA	J:143168
Cellular Component	GO:0005615	extracellular space	IDA	J:219495
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	ISO	J:155856
Biological Process	GO:0071347	cellular response to interleukin-1	IDA	J:151963
Biological Process	GO:0050832	defense response to fungus	IMP	J:161934
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:143719
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IDA	J:161481
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:143719
Biological Process	GO:0072537	fibroblast activation	ISO	J:164563
Biological Process	GO:0010467	gene expression	IDA	J:277730
Biological Process	GO:0097530	granulocyte migration	IGI	J:263441
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038173	interleukin-17A-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060729	intestinal epithelial structure maintenance	IMP	J:233769
Biological Process	GO:0030216	keratinocyte differentiation	IDA	J:277730
Biological Process	GO:0043616	keratinocyte proliferation	IMP	J:277730
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding	IDA	J:242717
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:250338
Biological Process	GO:0002225	positive regulation of antimicrobial peptide production	IDA	J:143719
Biological Process	GO:1903348	positive regulation of bicellular tight junction assembly	IMP	J:233769
Biological Process	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	IDA	J:155093
Biological Process	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	ISO	J:164563
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IDA	J:153850
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IGI	J:134412
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IGI	J:134412
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0032739	positive regulation of interleukin-16 production	ISO	J:164563
Biological Process	GO:0032747	positive regulation of interleukin-23 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:161934
Biological Process	GO:0010940	positive regulation of necrotic cell death	ISO	J:155856
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:124638
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:124638
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563