GO Annotations Graph

• Symbol: Lefty1
• Name: left right determination factor 1
• ID: MGI:107405

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Molecular Function	GO:0038100	nodal binding	IPI	J:90108
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IDA	J:90108
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1181347
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1181357
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0009948	anterior/posterior axis specification	IGI	J:90040
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0042074	cell migration involved in gastrulation	IGI	J:90040
Biological Process	GO:0008283	cell population proliferation	IGI	J:90040
Biological Process	GO:0008283	cell population proliferation	IGI	J:90040
Biological Process	GO:0007368	determination of left/right symmetry	IDA	J:49484
Biological Process	GO:0003007	heart morphogenesis	IMP	J:49484
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:90040
Biological Process	GO:1900124	negative regulation of nodal receptor complex assembly	IDA	J:90108
Biological Process	GO:1900108	negative regulation of nodal signaling pathway	IDA	J:90108
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:49484
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	J:265628
Biological Process	GO:0032526	response to retinoic acid	IDA	J:57950
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628