GO Annotations Graph

• Symbol: Tnfsf10
• Name: tumor necrosis factor (ligand) superfamily, member 10
• ID: MGI:107414

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0045569	TRAIL binding	IDA	J:81898
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	IEA	J:72247
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	IPI	J:81898
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	IPI	J:81898
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IDA	J:97777
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	ISO	J:164563