GO Annotations Graph

• Symbol: Numb
• Name: NUMB endocytic adaptor protein
• ID: MGI:107423

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0045294	alpha-catenin binding	IPI	J:124218
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:124218
Molecular Function	GO:0045296	cadherin binding	IPI	J:124218
Molecular Function	GO:0045296	cadherin binding	IPI	J:124218
Molecular Function	GO:0005515	protein binding	IPI	J:213895
Molecular Function	GO:0005515	protein binding	IPI	J:175332
Molecular Function	GO:0005515	protein binding	IPI	J:127227
Molecular Function	GO:0005515	protein binding	IPI	J:310319
Molecular Function	GO:0005515	protein binding	IPI	J:310319
Molecular Function	GO:0005515	protein binding	IPI	J:73266
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0045177	apical part of cell	IDA	J:79396
Cellular Component	GO:0045177	apical part of cell	IDA	J:171504
Cellular Component	GO:0045177	apical part of cell	IDA	J:171504
Cellular Component	GO:0045177	apical part of cell	IDA	J:171504
Cellular Component	GO:0045177	apical part of cell	IDA	J:171504
Cellular Component	GO:0016323	basolateral plasma membrane	IBA	J:265628
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:124218
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:227201
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:215867
Cellular Component	GO:0031410	cytoplasmic vesicle	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005769	early endosome	IDA	J:73901
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:228200
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:228200
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:228200
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:228200
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:228200
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2077477
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2077479
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Biological Process	GO:0034332	adherens junction organization	IGI	J:124218
Biological Process	GO:0007409	axonogenesis	IDA	J:95688
Biological Process	GO:0007409	axonogenesis	IMP	J:95688
Biological Process	GO:0030900	forebrain development	IMP	J:87149
Biological Process	GO:0021670	lateral ventricle development	IMP	J:127227
Biological Process	GO:0060487	lung epithelial cell differentiation	IMP	J:171504
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IMP	J:171504
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IMP	J:62712
Biological Process	GO:0007399	nervous system development	IMP	J:87149
Biological Process	GO:0021849	neuroblast division in subventricular zone	IMP	J:127227
Biological Process	GO:0007405	neuroblast proliferation	IGI	J:79917
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	ISO	J:155856
Biological Process	GO:0050769	positive regulation of neurogenesis	IMP	J:79917
Biological Process	GO:0050769	positive regulation of neurogenesis	IBA	J:265628
Biological Process	GO:0030862	positive regulation of polarized epithelial cell differentiation	IMP	J:171504
Biological Process	GO:0045664	regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0150052	regulation of postsynapse assembly	ISO	J:155856
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IDA	J:228200
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IDA	J:228200
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IDA	J:228200
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IEP	J:228200
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IMP	J:228200