Gdnf GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Gdnf
glial cell line derived neurotrophic factor
MGI:107430

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030116	glial cell-derived neurotrophic factor receptor binding	ISO	J:155856
Molecular Function	GO:0008083	growth factor activity	ISO	J:155856
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:155856
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	TAS	J:54911
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:155856
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IMP	J:33810
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IDA	J:85564
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IDA	J:171473
Biological Process	GO:0008283	cell population proliferation	ISO	J:155856
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	ISO	J:155856
Biological Process	GO:0071679	commissural neuron axon guidance	IGI	J:188327
Biological Process	GO:0021516	dorsal spinal cord development	IMP	J:188327
Biological Process	GO:0048568	embryonic organ development	IMP	J:188327
Biological Process	GO:0048484	enteric nervous system development	IMP	J:33809
Biological Process	GO:0048484	enteric nervous system development	IDA	J:33808
Biological Process	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	IEP	J:54493
Biological Process	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO	J:155856
Biological Process	GO:0001656	metanephros development	IMP	J:33808
Biological Process	GO:0001656	metanephros development	IGI	J:122519
Biological Process	GO:0001656	metanephros development	IGI	J:90324
Biological Process	GO:0001656	metanephros development	IMP	J:122519
Biological Process	GO:0048255	mRNA stabilization	ISO	J:164563
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IBA	J:265628
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:95816
Biological Process	GO:0007399	nervous system development	IMP	J:33808
Biological Process	GO:0001755	neural crest cell migration	ISO	J:73065
Biological Process	GO:1901166	neural crest cell migration involved in autonomic nervous system development	ISO	J:229828
Biological Process	GO:0030182	neuron differentiation	ISO	J:155856
Biological Process	GO:0031175	neuron projection development	ISO	J:73065
Biological Process	GO:0001759	organ induction	IGI	J:96485
Biological Process	GO:0007422	peripheral nervous system development	IBA	J:265628
Biological Process	GO:0007422	peripheral nervous system development	IMP	J:95816
Biological Process	GO:0007422	peripheral nervous system development	IMP	J:73922
Biological Process	GO:0030432	peristalsis	IMP	J:33810
Biological Process	GO:0030432	peristalsis	IMP	J:73922
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	ISO	J:164563
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	ISO	J:155856
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IMP	J:175174
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IBA	J:265628
Biological Process	GO:0045597	positive regulation of cell differentiation	ISO	J:202649
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:202649
Biological Process	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IMP	J:33809
Biological Process	GO:0032770	positive regulation of monooxygenase activity	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0072107	positive regulation of ureteric bud formation	ISO	J:164563
Biological Process	GO:0021784	postganglionic parasympathetic fiber development	IMP	J:33810
Biological Process	GO:0001941	postsynaptic membrane organization	IDA	J:93581
Biological Process	GO:0051584	regulation of dopamine uptake involved in synaptic transmission	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	ISO	J:202649
Biological Process	GO:0060688	regulation of morphogenesis of a branching structure	IDA	J:85564
Biological Process	GO:2001260	regulation of semaphorin-plexin signaling pathway	IGI	J:188327
Biological Process	GO:0072106	regulation of ureteric bud formation	ISO	J:155856
Biological Process	GO:0009611	response to wounding	ISO	J:155856
Biological Process	GO:0048485	sympathetic nervous system development	IMP	J:33808
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	TAS	J:54911
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	J:72723
Biological Process	GO:0001657	ureteric bud development	IDA	J:99437
Biological Process	GO:0001657	ureteric bud development	IGI	J:96485
Biological Process	GO:0060676	ureteric bud formation	IMP	J:33810

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/24/2024 MGI 6.24