GO Annotations Graph

• Symbol: Capn3
• Name: calpain 3
• ID: MGI:107437

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IDA	J:165998
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	ISO	J:155856
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IDA	J:91206
Molecular Function	GO:0003824	catalytic activity	ISO	J:164563
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0055103	ligase regulator activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	IMP	J:140035
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:282614
Molecular Function	GO:0005515	protein binding	IPI	J:87870
Molecular Function	GO:0005515	protein binding	IPI	J:160150
Molecular Function	GO:0005515	protein binding	IPI	J:91206
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0031402	sodium ion binding	IDA	J:165998
Molecular Function	GO:0008307	structural constituent of muscle	IMP	J:140035
Molecular Function	GO:0031432	titin binding	ISO	J:155856
Molecular Function	GO:0031432	titin binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:180460
Cellular Component	GO:0005737	cytoplasm	IDA	J:180556
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:140035
Cellular Component	GO:0030016	myofibril	ISO	J:155856
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:140035
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:140035
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Biological Process	GO:1990092	calcium-dependent self proteolysis	ISO	J:164563
Biological Process	GO:0071277	cellular response to calcium ion	IDA	J:165998
Biological Process	GO:0071472	cellular response to salt stress	IDA	J:165998
Biological Process	GO:0070315	G1 to G0 transition involved in cell differentiation	IDA	J:180556
Biological Process	GO:0061061	muscle structure development	IMP	J:140035
Biological Process	GO:0030239	myofibril assembly	IMP	J:91206
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:180460
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:180556
Biological Process	GO:0033234	negative regulation of protein sumoylation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:180460
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:180460
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0045862	positive regulation of proteolysis	IDA	J:180556
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	IMP	J:140035
Biological Process	GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration	IDA	J:180556
Biological Process	GO:0012501	programmed cell death	IDA	J:165998
Biological Process	GO:0030163	protein catabolic process	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0072657	protein localization to membrane	IMP	J:140035
Biological Process	GO:0065003	protein-containing complex assembly	IMP	J:140035
Biological Process	GO:0006508	proteolysis	IDA	J:165998
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:155856
Biological Process	GO:0006508	proteolysis	IBA	J:265628
Biological Process	GO:0006508	proteolysis	IDA	J:91206
Biological Process	GO:0050790	regulation of catalytic activity	ISO	J:164563
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:180460
Biological Process	GO:0045661	regulation of myoblast differentiation	IDA	J:180556
Biological Process	GO:0051592	response to calcium ion	ISO	J:155856
Biological Process	GO:0014850	response to muscle activity	ISO	J:155856
Biological Process	GO:0045214	sarcomere organization	IMP	J:91206
Biological Process	GO:0097264	self proteolysis	ISO	J:164563
Biological Process	GO:0097264	self proteolysis	ISO	J:155856
Biological Process	GO:1990091	sodium-dependent self proteolysis	ISO	J:155856