GO Annotations Graph

• Symbol: Dld
• Name: dihydrolipoamide dehydrogenase
• ID: MGI:107450

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004148	dihydrolipoyl dehydrogenase activity	ISO	J:164563
Molecular Function	GO:0004148	dihydrolipoyl dehydrogenase activity	ISO	J:155856
Molecular Function	GO:0004148	dihydrolipoyl dehydrogenase activity	IBA	J:265628
Molecular Function	GO:0004148	dihydrolipoyl dehydrogenase activity	IMP	J:45074
Molecular Function	GO:0004148	dihydrolipoyl dehydrogenase activity	IMP	J:45074
Molecular Function	GO:0004148	dihydrolipoyl dehydrogenase activity	IMP	J:45074
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:155856
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	IBA	J:265628
Molecular Function	GO:0043544	lipoamide binding	ISO	J:155856
Molecular Function	GO:0051287	NAD binding	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:263469
Molecular Function	GO:0034604	pyruvate dehydrogenase (NAD+) activity	ISO	J:73065
Molecular Function	GO:0034604	pyruvate dehydrogenase (NAD+) activity	IC	J:45074
Cellular Component	GO:1902493	acetyltransferase complex	IMP	J:45074
Cellular Component	GO:0043159	acrosomal matrix	IDA	J:100834
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005929	cilium	IDA	J:100834
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0045240	dihydrolipoyl dehydrogenase complex	IMP	J:45074
Cellular Component	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:45074
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	ISO	J:164563
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	IMP	J:45074
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:100834
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0031514	motile cilium	IEA	J:60000
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0045252	oxoglutarate dehydrogenase complex	ISO	J:164563
Cellular Component	GO:0045252	oxoglutarate dehydrogenase complex	ISO	J:155856
Cellular Component	GO:0045252	oxoglutarate dehydrogenase complex	IBA	J:265628
Cellular Component	GO:0045252	oxoglutarate dehydrogenase complex	IMP	J:133657
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	ISO	J:155856
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	ISO	J:73065
Biological Process	GO:0006103	2-oxoglutarate metabolic process	ISO	J:155856
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	ISO	J:155856
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	IMP	J:238348
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	IMP	J:123893
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	ISO	J:73065
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	IC	J:45074
Biological Process	GO:0009083	branched-chain amino acid catabolic process	ISO	J:164563
Biological Process	GO:0045454	cell redox homeostasis	IEA	J:72247
Biological Process	GO:0051068	dihydrolipoamide metabolic process	ISO	J:155856
Biological Process	GO:0007369	gastrulation	IMP	J:45074
Biological Process	GO:0106077	histone succinylation	ISO	J:164563
Biological Process	GO:0009106	lipoate metabolic process	ISO	J:155856
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	IMP	J:107994
Biological Process	GO:0006508	proteolysis	IDA	J:120800
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:107994
Biological Process	GO:0048240	sperm capacitation	IDA	J:100834