GO Annotations Graph

• Symbol: Alox5ap
• Name: arachidonate 5-lipoxygenase activating protein
• ID: MGI:107505

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	ISO	J:155856
Molecular Function	GO:0050544	arachidonic acid binding	ISO	J:164563
Molecular Function	GO:0008047	enzyme activator activity	IEA	J:72247
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0004602	glutathione peroxidase activity	IBA	J:265628
Molecular Function	GO:0004364	glutathione transferase activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0004464	leukotriene-C4 synthase activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:142670
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005635	nuclear envelope	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005635	nuclear envelope	IBA	J:265628
Cellular Component	GO:0031965	nuclear membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:142670
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:164563
Biological Process	GO:0019370	leukotriene biosynthetic process	ISO	J:155856
Biological Process	GO:0019370	leukotriene biosynthetic process	ISO	J:164563
Biological Process	GO:0019370	leukotriene biosynthetic process	IBA	J:265628
Biological Process	GO:0019370	leukotriene biosynthetic process	IMP	J:39229
Biological Process	GO:0019370	leukotriene biosynthetic process	IDA	J:142670
Biological Process	GO:0006691	leukotriene metabolic process	IEA	J:72247
Biological Process	GO:0002540	leukotriene production involved in inflammatory response	IMP	J:39229
Biological Process	GO:0002540	leukotriene production involved in inflammatory response	IMP	J:124522
Biological Process	GO:0019372	lipoxygenase pathway	ISO	J:155856
Biological Process	GO:0002675	positive regulation of acute inflammatory response	ISO	J:155856
Biological Process	GO:0070207	protein homotrimerization	ISO	J:164563