GO Annotations Graph

• Symbol: Sema5a
• Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
• ID: MGI:107556

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008046	axon guidance receptor activity	IDA	J:80875
Molecular Function	GO:0045499	chemorepellent activity	IBA	J:265628
Molecular Function	GO:0035373	chondroitin sulfate proteoglycan binding	ISO	J:155856
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	ISO	J:155856
Molecular Function	GO:0030215	semaphorin receptor binding	IPI	J:203408
Molecular Function	GO:0030215	semaphorin receptor binding	IBA	J:265628
Molecular Function	GO:0045545	syndecan binding	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:80875
Biological Process	GO:0048675	axon extension	IBA	J:265628
Biological Process	GO:0048675	axon extension	IGI	J:174679
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0007411	axon guidance	IMP	J:80875
Biological Process	GO:0007413	axonal fasciculation	ISO	J:155856
Biological Process	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	J:203404
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:97663
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IMP	J:97663
Biological Process	GO:0060326	cell chemotaxis	IDA	J:203408
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0050908	detection of light stimulus involved in visual perception	IGI	J:174679
Biological Process	GO:0021536	diencephalon development	ISO	J:155856
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	ISO	J:155856
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	IBA	J:265628
Biological Process	GO:0007162	negative regulation of cell adhesion	IDA	J:203408
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	IDA	J:203404
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0001755	neural crest cell migration	IBA	J:265628
Biological Process	GO:1990138	neuron projection extension	IGI	J:174679
Biological Process	GO:1990138	neuron projection extension	IGI	J:174679
Biological Process	GO:1990138	neuron projection extension	IDA	J:174679
Biological Process	GO:0097485	neuron projection guidance	IGI	J:174679
Biological Process	GO:0050918	positive chemotaxis	IDA	J:203408
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	IDA	J:203404
Biological Process	GO:0045766	positive regulation of angiogenesis	IDA	J:203404
Biological Process	GO:0048842	positive regulation of axon extension involved in axon guidance	ISO	J:155856
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IDA	J:203404
Biological Process	GO:0030335	positive regulation of cell migration	IBA	J:265628
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis	IDA	J:203404
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	IDA	J:203404
Biological Process	GO:0090091	positive regulation of extracellular matrix disassembly	NAS	J:203404
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IDA	J:203404
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IDA	J:203408
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IBA	J:265628
Biological Process	GO:1990256	signal clustering	IDA	J:203408
Biological Process	GO:1990256	signal clustering	ISO	J:155856