GO Annotations Graph

• Symbol: Sema4a
• Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
• ID: MGI:107560

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0045499	chemorepellent activity	IBA	J:265628
Molecular Function	GO:0030215	semaphorin receptor binding	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0007409	axonogenesis	IMP	J:182481
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0050919	negative chemotaxis	IBA	J:265628
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:119828
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	IBA	J:265628
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0001755	neural crest cell migration	IBA	J:265628
Biological Process	GO:0030335	positive regulation of cell migration	IBA	J:265628
Biological Process	GO:1904891	positive regulation of excitatory synapse assembly	IMP	J:268255
Biological Process	GO:1905704	positive regulation of inhibitory synapse assembly	IMP	J:268255
Biological Process	GO:0008360	regulation of cell shape	IDA	J:182481
Biological Process	GO:0010594	regulation of endothelial cell migration	IMP	J:119828
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IDA	J:182481
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IMP	J:119828
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IBA	J:265628
Biological Process	GO:0002292	T cell differentiation involved in immune response	IMP	J:97027
Biological Process	GO:0045063	T-helper 1 cell differentiation	IMP	J:97027