GO Annotations Graph

• Symbol: Hmgcs1
• Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
• ID: MGI:107592

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016746	acyltransferase activity	IEA	J:72247
Molecular Function	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	ISO	J:155856
Molecular Function	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	IBA	J:265628
Molecular Function	GO:0016853	isomerase activity	ISO	J:155856
Molecular Function	GO:0043177	organic acid binding	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0036094	small molecule binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Biological Process	GO:0006084	acetyl-CoA metabolic process	IBA	J:265628
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	ISO	J:155856
Biological Process	GO:0006695	cholesterol biosynthetic process	IEA	J:60000
Biological Process	GO:0008203	cholesterol metabolic process	IEA	J:60000
Biological Process	GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	IBA	J:265628
Biological Process	GO:0008299	isoprenoid biosynthetic process	IEA	J:72247
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0014074	response to purine-containing compound	ISO	J:155856
Biological Process	GO:0006694	steroid biosynthetic process	IEA	J:60000
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0016126	sterol biosynthetic process	IEA	J:60000