GO Annotations Graph

• Symbol: Il11
• Name: interleukin 11
• ID: MGI:107613

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IDA	J:21233
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0008083	growth factor activity	ISS	J:38817
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0005142	interleukin-11 receptor binding	IPI	J:21233
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:73394
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IDA	J:21233
Biological Process	GO:0038154	interleukin-11-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0046888	negative regulation of hormone secretion	ISO	J:73065
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:21233
Biological Process	GO:0043410	positive regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:73065
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:73065
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065