GO Annotations Graph

• Symbol: Ifng
• Name: interferon gamma
• ID: MGI:107656

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IDA	J:85159
Molecular Function	GO:0005125	cytokine activity	IDA	J:91936
Molecular Function	GO:0005125	cytokine activity	IDA	J:88533
Molecular Function	GO:0005125	cytokine activity	IDA	J:83995
Molecular Function	GO:0005515	protein binding	IPI	J:136267
Molecular Function	GO:0005133	type II interferon receptor binding	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:123631
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:175944
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:174389
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:118947
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:173331
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:168252
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:160369
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:165919
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:157744
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:213232
Cellular Component	GO:0005615	extracellular space	IDA	J:65439
Cellular Component	GO:0005615	extracellular space	IDA	J:143981
Cellular Component	GO:0005615	extracellular space	IDA	J:53400
Cellular Component	GO:0005615	extracellular space	IDA	J:172134
Cellular Component	GO:0005615	extracellular space	IDA	J:91286
Cellular Component	GO:0005615	extracellular space	IDA	J:116306
Cellular Component	GO:0005615	extracellular space	IDA	J:91804
Cellular Component	GO:0005615	extracellular space	IDA	J:111178
Cellular Component	GO:0005615	extracellular space	IDA	J:143168
Cellular Component	GO:0005615	extracellular space	IDA	J:140498
Cellular Component	GO:0005615	extracellular space	IDA	J:147177
Cellular Component	GO:0005615	extracellular space	IDA	J:91939
Cellular Component	GO:0005615	extracellular space	IDA	J:75400
Cellular Component	GO:0005615	extracellular space	IDA	J:165738
Cellular Component	GO:0005615	extracellular space	IDA	J:94032
Cellular Component	GO:0005615	extracellular space	IDA	J:117165
Cellular Component	GO:0005615	extracellular space	IDA	J:98417
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Biological Process	GO:0002250	adaptive immune response	IBA	J:265628
Biological Process	GO:0002250	adaptive immune response	IDA	J:143981
Biological Process	GO:0019882	antigen processing and presentation	IDA	J:92742
Biological Process	GO:0006915	apoptotic process	ISO	J:73065
Biological Process	GO:0048143	astrocyte activation	ISO	J:164563
Biological Process	GO:0048143	astrocyte activation	IGI	J:160440
Biological Process	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response	IDA	J:143981
Biological Process	GO:0071351	cellular response to interleukin-18	IDA	J:151963
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:142604
Biological Process	GO:0042742	defense response to bacterium	IDA	J:91936
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:295244
Biological Process	GO:0042832	defense response to protozoan	IDA	J:142066
Biological Process	GO:0042832	defense response to protozoan	IMP	J:111178
Biological Process	GO:0051607	defense response to virus	IDA	J:157631
Biological Process	GO:0051607	defense response to virus	IDA	J:222462
Biological Process	GO:0051607	defense response to virus	IGI	J:222462
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:99655
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0006959	humoral immune response	IBA	J:265628
Biological Process	GO:0006959	humoral immune response	IDA	J:143981
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006925	inflammatory cell apoptotic process	IMP	J:87535
Biological Process	GO:0032615	interleukin-12 production	IDA	J:111178
Biological Process	GO:0002281	macrophage activation involved in immune response	ISO	J:164563
Biological Process	GO:0010934	macrophage cytokine production	IDA	J:111178
Biological Process	GO:0030225	macrophage differentiation	ISO	J:164563
Biological Process	GO:0001774	microglial cell activation	IGI	J:274855
Biological Process	GO:0001774	microglial cell activation	IGI	J:232260
Biological Process	GO:0001774	microglial cell activation	IGI	J:160440
Biological Process	GO:0001774	microglial cell activation	ISO	J:164563
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:1900222	negative regulation of amyloid-beta clearance	IGI	J:117817
Biological Process	GO:1900222	negative regulation of amyloid-beta clearance	IDA	J:274783
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:197027
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	ISO	J:155856
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:274783
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:274783
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0072125	negative regulation of glomerular mesangial cell proliferation	ISO	J:155856
Biological Process	GO:0032700	negative regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0031642	negative regulation of myelination	IDA	J:99655
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	IDA	J:145836
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:1902948	negative regulation of tau-protein kinase activity	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0150076	neuroinflammatory response	ISO	J:155856
Biological Process	GO:0001781	neutrophil apoptotic process	IMP	J:85159
Biological Process	GO:0030593	neutrophil chemotaxis	IMP	J:85159
Biological Process	GO:0030593	neutrophil chemotaxis	IDA	J:85159
Biological Process	GO:0006809	nitric oxide biosynthetic process	IDA	J:67213
Biological Process	GO:0044794	positive regulation by host of viral process	IGI	J:166251
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	IGI	J:117817
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	IDA	J:117817
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	ISO	J:164563
Biological Process	GO:0032834	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:1901857	positive regulation of cellular respiration	IDA	J:274783
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:85159
Biological Process	GO:0032722	positive regulation of chemokine production	IDA	J:85159
Biological Process	GO:1904798	positive regulation of core promoter binding	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:86244
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:0060550	positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity	ISO	J:164563
Biological Process	GO:0060552	positive regulation of fructose 1,6-bisphosphate metabolic process	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:274783
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0045821	positive regulation of glycolytic process	IDA	J:274783
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:232260
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:85159
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:111178
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:86244
Biological Process	GO:0032747	positive regulation of interleukin-23 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:85159
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:85159
Biological Process	GO:1904440	positive regulation of iron ion import across plasma membrane	IDA	J:274783
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IDA	J:84929
Biological Process	GO:0051712	positive regulation of killing of cells of another organism	ISO	J:164563
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:111178
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	IGI	J:232260
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	IDA	J:169823
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	IDA	J:169824
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	IDA	J:169912
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	IDA	J:88533
Biological Process	GO:0050769	positive regulation of neurogenesis	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	IGI	J:274855
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IDA	J:67213
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	IGI	J:232260
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	IDA	J:274783
Biological Process	GO:0051173	positive regulation of nitrogen compound metabolic process	IGI	J:274855
Biological Process	GO:0051173	positive regulation of nitrogen compound metabolic process	ISO	J:164563
Biological Process	GO:1904783	positive regulation of NMDA glutamate receptor activity	ISO	J:155856
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	ISO	J:164563
Biological Process	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	ISO	J:155856
Biological Process	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	ISO	J:107465
Biological Process	GO:0050766	positive regulation of phagocytosis	IDA	J:160440
Biological Process	GO:0090312	positive regulation of protein deacetylation	ISO	J:164563
Biological Process	GO:0090312	positive regulation of protein deacetylation	IDA	J:197027
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:164563
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:2000273	positive regulation of signaling receptor activity	IGI	J:232260
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:0032224	positive regulation of synaptic transmission, cholinergic	ISO	J:155856
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:107465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:155210
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:155210
Biological Process	GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:232260
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:274855
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:117817
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:169912
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:169823
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:274783
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:107465
Biological Process	GO:0060557	positive regulation of vitamin D biosynthetic process	ISO	J:164563
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IGI	J:232260
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IGI	J:232260
Biological Process	GO:0050691	regulation of defense response to virus by host	IDA	J:213232
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:78558
Biological Process	GO:0060251	regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0040008	regulation of growth	IEA	J:60000
Biological Process	GO:2000345	regulation of hepatocyte proliferation	ISO	J:155856
Biological Process	GO:0050776	regulation of immune response	IDA	J:84929
Biological Process	GO:0050796	regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0098908	regulation of neuronal action potential	ISO	J:155856
Biological Process	GO:0002026	regulation of the force of heart contraction	ISO	J:155856
Biological Process	GO:0009615	response to virus	ISO	J:107465
Biological Process	GO:0050954	sensory perception of mechanical stimulus	ISO	J:155856
Biological Process	GO:0042098	T cell proliferation	IDA	J:107465
Biological Process	GO:0050852	T cell receptor signaling pathway	IDA	J:173261
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	IDA	J:197027
Biological Process	GO:0038196	type III interferon-mediated signaling pathway	ISO	J:164563