Casp4 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Casp4
caspase 4, apoptosis-related cysteine peptidase
MGI:107700

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050700	CARD domain binding	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:319864
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IMP	J:267416
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:296118
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:265832
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:265832
Molecular Function	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:164563
Molecular Function	GO:0001530	lipopolysaccharide binding	IDA	J:332656
Molecular Function	GO:0001530	lipopolysaccharide binding	IDA	J:332656
Molecular Function	GO:0008233	peptidase activity	RCA	J:84168
Molecular Function	GO:0005515	protein binding	IPI	J:273511
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Cellular Component	GO:0061702	canonical inflammasome complex	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:131780
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:131780
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0072558	NLRP1 inflammasome complex	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0007015	actin filament organization	TAS	J:180458
Biological Process	GO:0140632	canonical inflammasome complex assembly	IMP	J:332990
Biological Process	GO:0140632	canonical inflammasome complex assembly	IDA	J:201144
Biological Process	GO:0140632	canonical inflammasome complex assembly	IDA	J:201075
Biological Process	GO:0140632	canonical inflammasome complex assembly	IDA	J:333171
Biological Process	GO:0042742	defense response to bacterium	IMP	J:193387
Biological Process	GO:0042742	defense response to bacterium	IDA	J:332656
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IDA	J:267416
Biological Process	GO:0032497	detection of lipopolysaccharide	IDA	J:333171
Biological Process	GO:0032497	detection of lipopolysaccharide	IDA	J:201144
Biological Process	GO:0032497	detection of lipopolysaccharide	IDA	J:201075
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IGI	J:115619
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IMP	J:115619
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:193522
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:193522
Biological Process	GO:0160075	non-canonical inflammasome complex assembly	IDA	J:265832
Biological Process	GO:0160075	non-canonical inflammasome complex assembly	IDA	J:332656
Biological Process	GO:0160075	non-canonical inflammasome complex assembly	IDA	J:265832
Biological Process	GO:0160075	non-canonical inflammasome complex assembly	IDA	J:332656
Biological Process	GO:0050729	positive regulation of inflammatory response	IMP	J:193387
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:319864
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:267416
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:193522
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	IDA	J:267416
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:193522
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:193522
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IDA	J:233045
Biological Process	GO:0012501	programmed cell death	IEA	J:60000
Biological Process	GO:0016540	protein autoprocessing	IDA	J:296118
Biological Process	GO:0016540	protein autoprocessing	IMP	J:267416
Biological Process	GO:0051604	protein maturation	IDA	J:265832
Biological Process	GO:0051604	protein maturation	IDA	J:265832
Biological Process	GO:0006508	proteolysis	RCA	J:84168
Biological Process	GO:0070269	pyroptosis	IDA	J:296118
Biological Process	GO:0070269	pyroptosis	IDA	J:333171
Biological Process	GO:0070269	pyroptosis	IDA	J:265832
Biological Process	GO:0070269	pyroptosis	IMP	J:193387
Biological Process	GO:0070269	pyroptosis	IDA	J:319864
Biological Process	GO:0070269	pyroptosis	IMP	J:193522
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0050727	regulation of inflammatory response	IDA	J:296118

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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