Casp3 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Casp3
caspase 3
MGI:107739

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	IDA	J:93470
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	IDA	J:199098
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IMP	J:85809
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:180563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:93322
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:87073
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:306586
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	IBA	J:265628
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:206879
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:101402
Molecular Function	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO	J:164563
Molecular Function	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	ISO	J:164563
Molecular Function	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	IDA	J:79113
Molecular Function	GO:0008234	cysteine-type peptidase activity	ISO	J:155856
Molecular Function	GO:0008234	cysteine-type peptidase activity	IDA	J:124808
Molecular Function	GO:0005123	death receptor binding	ISO	J:155856
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:79113
Molecular Function	GO:0004857	enzyme inhibitor activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IDA	J:87334
Molecular Function	GO:0008233	peptidase activity	IMP	J:71535
Molecular Function	GO:0008233	peptidase activity	IDA	J:85814
Molecular Function	GO:0008233	peptidase activity	IMP	J:71535
Molecular Function	GO:0008233	peptidase activity	RCA	J:84168
Molecular Function	GO:0008233	peptidase activity	ISO	J:73065
Molecular Function	GO:0008233	peptidase activity	IMP	J:85809
Molecular Function	GO:0008233	peptidase activity	IDA	J:85343
Molecular Function	GO:0008233	peptidase activity	IDA	J:109212
Molecular Function	GO:0008233	peptidase activity	IMP	J:105496
Molecular Function	GO:0016005	phospholipase A2 activator activity	ISO	J:155856
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:136306
Molecular Function	GO:0005515	protein binding	IPI	J:180563
Molecular Function	GO:0005515	protein binding	IPI	J:200423
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0008303	caspase complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:194718
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:81904
Cellular Component	GO:0005737	cytoplasm	IDA	J:204287
Cellular Component	GO:0005737	cytoplasm	IDA	J:220106
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-418855
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2534247
Cellular Component	GO:0031264	death-inducing signaling complex	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:181629
Biological Process	GO:0061713	anterior neural tube closure	IMP	J:174027
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	IMP	J:85809
Biological Process	GO:0006915	apoptotic process	IMP	J:74972
Biological Process	GO:0007413	axonal fasciculation	ISO	J:155856
Biological Process	GO:0001782	B cell homeostasis	IMP	J:85809
Biological Process	GO:0045165	cell fate commitment	IMP	J:90057
Biological Process	GO:0071310	cellular response to organic substance	IDA	J:83575
Biological Process	GO:0072734	cellular response to staurosporine	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IDA	J:115386
Biological Process	GO:1904019	epithelial cell apoptotic process	IDA	J:130045
Biological Process	GO:0030218	erythrocyte differentiation	ISO	J:164563
Biological Process	GO:0030218	erythrocyte differentiation	IBA	J:265628
Biological Process	GO:0097194	execution phase of apoptosis	ISO	J:164563
Biological Process	GO:0097194	execution phase of apoptosis	IMP	J:36821
Biological Process	GO:0097194	execution phase of apoptosis	IMP	J:71535
Biological Process	GO:0097194	execution phase of apoptosis	IGI	J:105496
Biological Process	GO:0097194	execution phase of apoptosis	IDA	J:85343
Biological Process	GO:0097194	execution phase of apoptosis	IDA	J:93322
Biological Process	GO:0097194	execution phase of apoptosis	IDA	J:79113
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IDA	J:151786
Biological Process	GO:0044346	fibroblast apoptotic process	IMP	J:105496
Biological Process	GO:0044346	fibroblast apoptotic process	IDA	J:84272
Biological Process	GO:0034349	glial cell apoptotic process	IMP	J:71535
Biological Process	GO:0034349	glial cell apoptotic process	IMP	J:71535
Biological Process	GO:0007507	heart development	IGI	J:105496
Biological Process	GO:0007507	heart development	IGI	J:105496
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	NAS	J:320304
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	NAS	J:220516
Biological Process	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress	IDA	J:194718
Biological Process	GO:0030216	keratinocyte differentiation	IBA	J:265628
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:90057
Biological Process	GO:0007611	learning or memory	ISO	J:155856
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	IMP	J:85809
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:73065
Biological Process	GO:0030889	negative regulation of B cell proliferation	IMP	J:85809
Biological Process	GO:0045786	negative regulation of cell cycle	IMP	J:85809
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IMP	J:85809
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:59317
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:59317
Biological Process	GO:0051402	neuron apoptotic process	IDA	J:109212
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:71535
Biological Process	GO:0051402	neuron apoptotic process	IDA	J:93470
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:57545
Biological Process	GO:0030182	neuron differentiation	IBA	J:265628
Biological Process	GO:0048011	neurotrophin TRK receptor signaling pathway	ISO	J:201759
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ISO	J:155856
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:1902512	positive regulation of apoptotic DNA fragmentation	IDA	J:314859
Biological Process	GO:1902512	positive regulation of apoptotic DNA fragmentation	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	IDA	J:194718
Biological Process	GO:0043065	positive regulation of apoptotic process	IDA	J:151786
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0140639	positive regulation of pyroptosis	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0051604	protein maturation	ISO	J:164563
Biological Process	GO:0016485	protein processing	IDA	J:93470
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:155856
Biological Process	GO:0006508	proteolysis	RCA	J:84168
Biological Process	GO:0031647	regulation of protein stability	ISO	J:155856
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0009749	response to glucose	ISO	J:155856
Biological Process	GO:0042542	response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	IDA	J:146128
Biological Process	GO:0009411	response to UV	IGI	J:105496
Biological Process	GO:0009411	response to UV	IDA	J:115386
Biological Process	GO:0009611	response to wounding	IDA	J:85750
Biological Process	GO:0007605	sensory perception of sound	IMP	J:69809
Biological Process	GO:0043029	T cell homeostasis	IMP	J:85809

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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