GO Annotations Graph

• Symbol: Pfkfb1
• Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
• ID: MGI:107816

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003873	6-phosphofructo-2-kinase activity	ISO	J:155856
Molecular Function	GO:0003873	6-phosphofructo-2-kinase activity	IBA	J:265628
Molecular Function	GO:0003873	6-phosphofructo-2-kinase activity	ISO	J:79155
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	ISO	J:164563
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	ISO	J:155856
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	IBA	J:265628
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	ISO	J:331970
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	ISO	J:331970
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	IGI	J:103418
Molecular Function	GO:0070095	fructose-6-phosphate binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0019209	kinase activator activity	ISO	J:79155
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0019900	kinase binding	ISO	J:155856
Molecular Function	GO:0019210	kinase inhibitor activity	ISO	J:331970
Molecular Function	GO:0019210	kinase inhibitor activity	IGI	J:103418
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0019211	phosphatase activator activity	ISO	J:331970
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	ISO	J:155856
Cellular Component	GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	ISO	J:164563
Cellular Component	GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:79155
Cellular Component	GO:0005829	cytosol	ISO	J:332286
Biological Process	GO:0046835	carbohydrate phosphorylation	ISO	J:155856
Biological Process	GO:0006003	fructose 2,6-bisphosphate metabolic process	ISO	J:164563
Biological Process	GO:0006003	fructose 2,6-bisphosphate metabolic process	IBA	J:265628
Biological Process	GO:0006000	fructose metabolic process	IEA	J:72247
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:1904539	negative regulation of glycolytic process through fructose-6-phosphate	IMP	J:94475
Biological Process	GO:1904539	negative regulation of glycolytic process through fructose-6-phosphate	IGI	J:103418
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0033133	positive regulation of glucokinase activity	ISO	J:155856
Biological Process	GO:0045722	positive regulation of gluconeogenesis	ISO	J:331947
Biological Process	GO:1904540	positive regulation of glycolytic process through fructose-6-phosphate	ISO	J:79155