GO Annotations Graph

• Symbol: Ctsk
• Name: cathepsin K
• ID: MGI:107823

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005518	collagen binding	ISO	J:164563
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	IBA	J:265628
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	ISO	J:154691
Molecular Function	GO:0001968	fibronectin binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0043394	proteoglycan binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:83877
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:83877
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IDA	J:83877
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IBA	J:265628
Cellular Component	GO:0005764	lysosome	IDA	J:261411
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0045453	bone resorption	ISO	J:155856
Biological Process	GO:0045453	bone resorption	IMP	J:154691
Biological Process	GO:0030574	collagen catabolic process	ISO	J:164563
Biological Process	GO:0030574	collagen catabolic process	ISO	J:154691
Biological Process	GO:0030574	collagen catabolic process	IMP	J:154691
Biological Process	GO:0006955	immune response	IBA	J:265628
Biological Process	GO:0061037	negative regulation of cartilage development	IMP	J:154691
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0010952	positive regulation of peptidase activity	IBA	J:265628
Biological Process	GO:0006508	proteolysis	ISO	J:155856
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	IMP	J:83877
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	IBA	J:265628
Biological Process	GO:0006590	thyroid hormone generation	IMP	J:83877
Biological Process	GO:0006590	thyroid hormone generation	ISO	J:164563