Adam8 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Adam8
a disintegrin and metallopeptidase domain 8
MGI:107825

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IDA	J:80712
Molecular Function	GO:0050839	cell adhesion molecule binding	IPI	J:164288
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:164563
Molecular Function	GO:0050839	cell adhesion molecule binding	IPI	J:169801
Molecular Function	GO:0050839	cell adhesion molecule binding	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005178	integrin binding	TAS	J:172989
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	IDA	J:89492
Molecular Function	GO:0008237	metallopeptidase activity	IDA	J:169801
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	IDA	J:80712
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:89492
Molecular Function	GO:0005515	protein binding	IPI	J:169801
Molecular Function	GO:0005515	protein binding	IPI	J:80712
Molecular Function	GO:0008270	zinc ion binding	IDA	J:169801
Molecular Function	GO:0008270	zinc ion binding	IDA	J:80712
Cellular Component	GO:0071133	alpha9-beta1 integrin-ADAM8 complex	IDA	J:128102
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0032127	dense core granule membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0032010	phagolysosome	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:80712
Cellular Component	GO:0002102	podosome	ISO	J:164563
Cellular Component	GO:0002102	podosome	TAS	J:172958
Cellular Component	GO:0042581	specific granule	ISO	J:164563
Cellular Component	GO:0070820	tertiary granule	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IDA	J:172962
Biological Process	GO:0043534	blood vessel endothelial cell migration	NAS	J:172962
Biological Process	GO:0000902	cell morphogenesis	IMP	J:172936
Biological Process	GO:0000902	cell morphogenesis	IMP	J:172898
Biological Process	GO:0098609	cell-cell adhesion	IDA	J:80712
Biological Process	GO:0007160	cell-matrix adhesion	TAS	J:172898
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	IMP	J:172944
Biological Process	GO:0048247	lymphocyte chemotaxis	IDA	J:165123
Biological Process	GO:0061025	membrane fusion	TAS	J:172898
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IDA	J:89492
Biological Process	GO:2000399	negative regulation of thymocyte aggregation	NAS	J:165123
Biological Process	GO:0072675	osteoclast fusion	TAS	J:80712
Biological Process	GO:0002675	positive regulation of acute inflammatory response	IMP	J:173132
Biological Process	GO:0045780	positive regulation of bone resorption	IMP	J:172936
Biological Process	GO:0045780	positive regulation of bone resorption	IDA	J:172898
Biological Process	GO:0045785	positive regulation of cell adhesion	IDA	J:80712
Biological Process	GO:0002693	positive regulation of cellular extravasation	IMP	J:172944
Biological Process	GO:0002693	positive regulation of cellular extravasation	IBA	J:265628
Biological Process	GO:2000418	positive regulation of eosinophil migration	IMP	J:172944
Biological Process	GO:2000415	positive regulation of fibronectin-dependent thymocyte migration	IMP	J:165123
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:172958
Biological Process	GO:0045089	positive regulation of innate immune response	IDA	J:172936
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IDA	J:172936
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	IDA	J:89492
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	IBA	J:265628
Biological Process	GO:2000391	positive regulation of neutrophil extravasation	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	J:172936
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IDA	J:172936
Biological Process	GO:0033089	positive regulation of T cell differentiation in thymus	IDA	J:165123
Biological Process	GO:2000406	positive regulation of T cell migration	IMP	J:172944
Biological Process	GO:0070245	positive regulation of thymocyte apoptotic process	IMP	J:165123
Biological Process	GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	IMP	J:172936
Biological Process	GO:0006508	proteolysis	IBA	J:265628
Biological Process	GO:0022407	regulation of cell-cell adhesion	ISO	J:164563
Biological Process	GO:0022407	regulation of cell-cell adhesion	IBA	J:265628
Biological Process	GO:0045670	regulation of osteoclast differentiation	NAS	J:174126
Biological Process	GO:0048729	tissue morphogenesis	TAS	J:172898

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24