Rock2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Rock2
Rho-associated coiled-coil containing protein kinase 2
MGI:107926

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:104536
Molecular Function	GO:0005515	protein binding	IPI	J:117631
Molecular Function	GO:0005515	protein binding	IPI	J:243147
Molecular Function	GO:0004672	protein kinase activity	ISO	J:73065
Molecular Function	GO:0004672	protein kinase activity	IDA	J:228158
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:268013
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:255339
Molecular Function	GO:0072518	Rho-dependent protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0072518	Rho-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0031267	small GTPase binding	IEA	J:72247
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005813	centrosome	IBA	J:265628
Cellular Component	GO:0005813	centrosome	IDA	J:117631
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:225274
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:225274
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:225274
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:225274
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:225274
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:225274
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:225274
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:225274
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:225274
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:225274
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Cellular Component	GO:0031616	spindle pole centrosome	IDA	J:117631
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:94515
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:103784
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:103784
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:103784
Biological Process	GO:0031032	actomyosin structure organization	IBA	J:265628
Biological Process	GO:0097746	blood vessel diameter maintenance	IMP	J:268013
Biological Process	GO:1905145	cellular response to acetylcholine	IMP	J:268013
Biological Process	GO:0071394	cellular response to testosterone stimulus	ISO	J:164563
Biological Process	GO:0051298	centrosome duplication	ISO	J:164563
Biological Process	GO:0051298	centrosome duplication	IMP	J:117631
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0030866	cortical actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0048813	dendrite morphogenesis	IGI	J:193891
Biological Process	GO:0048598	embryonic morphogenesis	IBA	J:265628
Biological Process	GO:0001837	epithelial to mesenchymal transition	IGI	J:94515
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IGI	J:104536
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IGI	J:104536
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0000281	mitotic cytokinesis	IBA	J:265628
Biological Process	GO:0044788	modulation by host of viral process	ISO	J:164563
Biological Process	GO:0061157	mRNA destabilization	IMP	J:268013
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:1903347	negative regulation of bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:268013
Biological Process	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	ISO	J:164563
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	IMP	J:268013
Biological Process	GO:0150033	negative regulation of protein localization to lysosome	ISO	J:164563
Biological Process	GO:0001843	neural tube closure	IGI	J:119920
Biological Process	GO:0001843	neural tube closure	IGI	J:119920
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:255339
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IMP	J:268013
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IMP	J:268013
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:1902993	positive regulation of amyloid precursor protein catabolic process	IMP	J:255339
Biological Process	GO:1902993	positive regulation of amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	IMP	J:255339
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IMP	J:255339
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ISO	J:155856
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	IMP	J:261839
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0010825	positive regulation of centrosome duplication	IMP	J:117631
Biological Process	GO:0032723	positive regulation of connective tissue growth factor production	ISO	J:155856
Biological Process	GO:1905205	positive regulation of connective tissue replacement	IMP	J:261839
Biological Process	GO:1905205	positive regulation of connective tissue replacement	ISO	J:155856
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0090271	positive regulation of fibroblast growth factor production	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:261839
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:261839
Biological Process	GO:1902966	positive regulation of protein localization to early endosome	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IDA	J:225274
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IDA	J:225274
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IDA	J:225274
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IDA	J:225274
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IDA	J:225274
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IMP	J:225274
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IDA	J:225274
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IDA	J:225274
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IMP	J:225274
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IDA	J:225274
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IMP	J:138635
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IEA	J:72247
Biological Process	GO:0110061	regulation of angiotensin-activated signaling pathway	IMP	J:261839
Biological Process	GO:1901888	regulation of cell junction assembly	IBA	J:265628
Biological Process	GO:1900037	regulation of cellular response to hypoxia	IMP	J:268013
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:209475
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0045616	regulation of keratinocyte differentiation	ISO	J:164563
Biological Process	GO:0031644	regulation of nervous system process	IMP	J:268013
Biological Process	GO:0051246	regulation of protein metabolic process	IMP	J:255339
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IMP	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:1990776	response to angiotensin	IGI	J:261839
Biological Process	GO:0002931	response to ischemia	IMP	J:268013
Biological Process	GO:0071559	response to transforming growth factor beta	ISO	J:155856
Biological Process	GO:0071559	response to transforming growth factor beta	IGI	J:261839
Biological Process	GO:0007266	Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:136004
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0006939	smooth muscle contraction	IEA	J:72247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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