GO Annotations Graph

• Symbol: Il18
• Name: interleukin 18
• ID: MGI:107936

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IMP	J:102800
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IDA	J:75400
Molecular Function	GO:0045515	interleukin-18 receptor binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:267416
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:113450
Cellular Component	GO:0005615	extracellular space	IDA	J:91804
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	ISS	J:114038
Biological Process	GO:0001525	angiogenesis	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IDA	J:98417
Biological Process	GO:0008283	cell population proliferation	IGI	J:98417
Biological Process	GO:0008283	cell population proliferation	IGI	J:98417
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:164563
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	ISO	J:155856
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:102800
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IDA	J:267416
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:227990
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	TAS	J:114012
Biological Process	GO:0006955	immune response	TAS	J:75903
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IGI	J:200244
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	IDA	J:267416
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	IDA	J:98417
Biological Process	GO:0032635	interleukin-6 production	IDA	J:98417
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0030101	natural killer cell activation	IDA	J:70298
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IDA	J:98417
Biological Process	GO:0045662	negative regulation of myoblast differentiation	IMP	J:204300
Biological Process	GO:0033030	negative regulation of neutrophil apoptotic process	ISO	J:155856
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0042119	neutrophil activation	IDA	J:98417
Biological Process	GO:0038061	NIK/NF-kappaB signaling	IDA	J:70298
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISO	J:164563
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISS	J:115169
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:2000504	positive regulation of blood vessel remodeling	ISO	J:155856
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:249916
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:151963
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	ISO	J:164563
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	IMP	J:227990
Biological Process	GO:0032736	positive regulation of interleukin-13 production	TAS	J:114011
Biological Process	GO:0032740	positive regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:155856
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	IMP	J:102800
Biological Process	GO:2000256	positive regulation of male germ cell proliferation	ISO	J:155856
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IDA	J:70298
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ISO	J:155856
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production	ISO	J:164563
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	IMP	J:102800
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:113976
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:98417
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:75401
Biological Process	GO:0032729	positive regulation of type II interferon production	IGI	J:98417
Biological Process	GO:0032729	positive regulation of type II interferon production	IGI	J:98417
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:70298
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:75400
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0043117	positive regulation of vascular permeability	ISO	J:155856
Biological Process	GO:0030155	regulation of cell adhesion	ISS	J:114036
Biological Process	GO:0030155	regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0030431	sleep	ISO	J:155856
Biological Process	GO:0030431	sleep	ISS	J:114042
Biological Process	GO:0035744	T-helper 1 cell cytokine production	IGI	J:98417
Biological Process	GO:0035744	T-helper 1 cell cytokine production	IGI	J:98417
Biological Process	GO:0035744	T-helper 1 cell cytokine production	IDA	J:98417
Biological Process	GO:0042088	T-helper 1 type immune response	ISO	J:164563
Biological Process	GO:0042088	T-helper 1 type immune response	ISS	J:115169
Biological Process	GO:0070328	triglyceride homeostasis	IMP	J:102800
Biological Process	GO:0032609	type II interferon production	IDA	J:75400
Biological Process	GO:0032609	type II interferon production	IDA	J:75401
Biological Process	GO:0032609	type II interferon production	IDA	J:70298