Slc8a2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Slc8a2
solute carrier family 8 (sodium/calcium exchanger), member 2
MGI:107996

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015297	antiporter activity	IEA	J:60000
Molecular Function	GO:0015085	calcium ion transmembrane transporter activity	IMP	J:136458
Molecular Function	GO:1905060	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISO	J:155856
Molecular Function	GO:0005432	calcium:sodium antiporter activity	IMP	J:84050
Molecular Function	GO:0005432	calcium:sodium antiporter activity	ISO	J:155856
Molecular Function	GO:0005432	calcium:sodium antiporter activity	IBA	J:265628
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0015081	sodium ion transmembrane transporter activity	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0043679	axon terminus	IMP	J:271785
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IMP	J:84050
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0098794	postsynapse	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	IMP	J:271785
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0098793	presynapse	ISO	J:164563
Cellular Component	GO:0042383	sarcolemma	IBA	J:265628
Cellular Component	GO:0045202	synapse	IDA	J:271785
Biological Process	GO:1990034	calcium ion export across plasma membrane	ISO	J:155856
Biological Process	GO:1990034	calcium ion export across plasma membrane	IMP	J:136458
Biological Process	GO:0098703	calcium ion import across plasma membrane	ISO	J:155856
Biological Process	GO:0098703	calcium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:84050
Biological Process	GO:0006816	calcium ion transport	IEA	J:72247
Biological Process	GO:0006816	calcium ion transport	IEA	J:60000
Biological Process	GO:0060402	calcium ion transport into cytosol	ISO	J:155856
Biological Process	GO:0007154	cell communication	IEA	J:72247
Biological Process	GO:0050890	cognition	IMP	J:282717
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:84050
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:155856
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:271785
Biological Process	GO:0007612	learning	IMP	J:84050
Biological Process	GO:0007611	learning or memory	IMP	J:271785
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:84050
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:271785
Biological Process	GO:0007613	memory	IMP	J:84050
Biological Process	GO:0098815	modulation of excitatory postsynaptic potential	IMP	J:271785
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0070050	neuron cellular homeostasis	IMP	J:136458
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	IMP	J:271785
Biological Process	GO:0099608	regulation of action potential firing pattern	IMP	J:136458
Biological Process	GO:0106056	regulation of calcineurin-mediated signaling	IMP	J:271785
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	IMP	J:136458
Biological Process	GO:0010468	regulation of gene expression	IMP	J:271785
Biological Process	GO:0010468	regulation of gene expression	IMP	J:271785
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	IMP	J:84050
Biological Process	GO:0002931	response to ischemia	IMP	J:136458
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:84050
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	ISO	J:155856
Biological Process	GO:0050808	synapse organization	IMP	J:271785
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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