GO Annotations Graph

• Symbol: Myd88
• Name: myeloid differentiation primary response gene 88
• ID: MGI:108005

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140674	ATP-dependent histone chaperone activity	IMP	J:136566
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005149	interleukin-1 receptor binding	ISO	J:155856
Molecular Function	GO:0005149	interleukin-1 receptor binding	IDA	J:64697
Molecular Function	GO:0019209	kinase activator activity	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:143338
Molecular Function	GO:0005515	protein binding	IPI	J:211317
Molecular Function	GO:0005515	protein binding	IPI	J:266414
Molecular Function	GO:0005515	protein binding	IPI	J:188561
Molecular Function	GO:0005515	protein binding	IPI	J:110094
Molecular Function	GO:0005515	protein binding	IPI	J:171920
Molecular Function	GO:0005515	protein binding	IPI	J:180126
Molecular Function	GO:0005515	protein binding	IPI	J:162535
Molecular Function	GO:0005515	protein binding	IPI	J:115304
Molecular Function	GO:0005515	protein binding	IPI	J:180054
Molecular Function	GO:0005515	protein binding	IPI	J:166021
Molecular Function	GO:0005515	protein binding	IPI	J:107309
Molecular Function	GO:0005515	protein binding	IPI	J:64697
Molecular Function	GO:0005515	protein binding	IPI	J:166021
Molecular Function	GO:0005515	protein binding	IPI	J:102933
Molecular Function	GO:0005515	protein binding	IPI	J:102933
Molecular Function	GO:0005515	protein binding	IPI	J:145929
Molecular Function	GO:0005515	protein binding	IPI	J:145929
Molecular Function	GO:0005515	protein binding	IPI	J:145929
Molecular Function	GO:0005515	protein binding	IPI	J:102933
Molecular Function	GO:0005515	protein binding	IPI	J:71392
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0070976	TIR domain binding	ISO	J:164563
Molecular Function	GO:0005121	Toll binding	ISO	J:155856
Molecular Function	GO:0035325	Toll-like receptor binding	IPI	J:231858
Molecular Function	GO:0035325	Toll-like receptor binding	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	TAS	J:57233
Cellular Component	GO:0005829	cytosol	IDA	J:171185
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0019897	extrinsic component of plasma membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:171185
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0070935	3'-UTR-mediated mRNA stabilization	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0007166	cell surface receptor signaling pathway	IMP	J:89998
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:277857
Biological Process	GO:0071310	cellular response to organic substance	IMP	J:277730
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	IMP	J:158401
Biological Process	GO:0032602	chemokine production	IGI	J:84679
Biological Process	GO:0006325	chromatin organization	IMP	J:136566
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:125955
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IBA	J:265628
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:106736
Biological Process	GO:0042832	defense response to protozoan	IMP	J:277857
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	IMP	J:180511
Biological Process	GO:0010467	gene expression	IMP	J:277730
Biological Process	GO:0010467	gene expression	IMP	J:136381
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:84679
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:84679
Biological Process	GO:0006955	immune response	TAS	J:72250
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0016064	immunoglobulin mediated immune response	IMP	J:97662
Biological Process	GO:0009682	induced systemic resistance	IMP	J:221015
Biological Process	GO:0006954	inflammatory response	IMP	J:136381
Biological Process	GO:0006954	inflammatory response	IMP	J:221015
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IDA	J:64697
Biological Process	GO:0032635	interleukin-6 production	IMP	J:106736
Biological Process	GO:0007254	JNK cascade	ISO	J:155856
Biological Process	GO:0007254	JNK cascade	IMP	J:84679
Biological Process	GO:0002269	leukocyte activation involved in inflammatory response	IGI	J:297349
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:84679
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:84896
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:110454
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:84896
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:106736
Biological Process	GO:0014004	microglia differentiation	IMP	J:136381
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IMP	J:88001
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IGI	J:89998
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IMP	J:84896
Biological Process	GO:0022008	neurogenesis	IMP	J:136381
Biological Process	GO:0002283	neutrophil activation involved in immune response	IGI	J:297349
Biological Process	GO:0070944	neutrophil-mediated killing of bacterium	IGI	J:297349
Biological Process	GO:0006909	phagocytosis	ISO	J:164563
Biological Process	GO:0006909	phagocytosis	IMP	J:273550
Biological Process	GO:0032722	positive regulation of chemokine production	IGI	J:84679
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IMP	J:158401
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:158401
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:84679
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:84679
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IMP	J:131398
Biological Process	GO:0032747	positive regulation of interleukin-23 production	IMP	J:131398
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:131398
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:106736
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:84679
Biological Process	GO:0050671	positive regulation of lymphocyte proliferation	IMP	J:110454
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:110454
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:106736
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:84896
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:106736
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:84896
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:145929
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	J:145929
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IGI	J:145929
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:84679
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IGI	J:84679
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:266673
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:84896
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:89998
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:110454
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:84896
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:106736
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:122812
Biological Process	GO:2000338	regulation of chemokine (C-X-C motif) ligand 1 production	IMP	J:221015
Biological Process	GO:2000341	regulation of chemokine (C-X-C motif) ligand 2 production	IMP	J:221015
Biological Process	GO:0010468	regulation of gene expression	IMP	J:146128
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:131398
Biological Process	GO:0032675	regulation of interleukin-6 production	IMP	J:221015
Biological Process	GO:1902622	regulation of neutrophil migration	IMP	J:221015
Biological Process	GO:0032680	regulation of tumor necrosis factor production	IMP	J:221015
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:110454
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:89998
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:84679
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:84896
Biological Process	GO:0032496	response to lipopolysaccharide	IGI	J:84896
Biological Process	GO:0002238	response to molecule of fungal origin	IMP	J:89998
Biological Process	GO:0032494	response to peptidoglycan	IMP	J:110454
Biological Process	GO:0009615	response to virus	IMP	J:88906
Biological Process	GO:0009615	response to virus	IMP	J:97662
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0043588	skin development	IMP	J:277730
Biological Process	GO:0008063	Toll signaling pathway	ISO	J:155856
Biological Process	GO:0008063	Toll signaling pathway	IBA	J:265628
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0034158	toll-like receptor 8 signaling pathway	ISO	J:164563
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	TAS	J:57233
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:84896
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:110454
Biological Process	GO:0032640	tumor necrosis factor production	IGI	J:84896
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:106736
Biological Process	GO:0032606	type I interferon production	IMP	J:97662
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	ISO	J:164563