GO Annotations Graph

• Symbol: Nkx3-2
• Name: NK3 homeobox 2
• ID: MGI:108015

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:210922
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:210922
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8985315
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0048513	animal organ development	IMP	J:148724
Biological Process	GO:0048645	animal organ formation	IMP	J:57112
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:93234
Biological Process	GO:0055123	digestive system development	IMP	J:148724
Biological Process	GO:0048706	embryonic skeletal system development	IMP	J:57112
Biological Process	GO:0048706	embryonic skeletal system development	IMP	J:57112
Biological Process	GO:0048706	embryonic skeletal system development	IMP	J:57112
Biological Process	GO:0048706	embryonic skeletal system development	IMP	J:55583
Biological Process	GO:0048706	embryonic skeletal system development	IMP	J:57112
Biological Process	GO:0060576	intestinal epithelial cell development	IGI	J:170489
Biological Process	GO:0042474	middle ear morphogenesis	IMP	J:88584
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:55583
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	IMP	J:105923
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:210922
Biological Process	GO:0031016	pancreas development	IMP	J:93234
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0001501	skeletal system development	IMP	J:93802
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:55583
Biological Process	GO:0048536	spleen development	IMP	J:148724
Biological Process	GO:0048536	spleen development	IMP	J:57112
Biological Process	GO:0048536	spleen development	IMP	J:55583
Biological Process	GO:0048536	spleen development	IMP	J:93234