GO Annotations Graph

• Symbol: Atr
• Name: ataxia telangiectasia and Rad3 related
• ID: MGI:108028

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:72247
Molecular Function	GO:0032405	MutLalpha complex binding	ISO	J:73065
Molecular Function	GO:0032407	MutSalpha complex binding	ISO	J:73065
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:164024
Molecular Function	GO:0005515	protein binding	IPI	J:96923
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	TAS	J:94951
Molecular Function	GO:0004672	protein kinase activity	IDA	J:92518
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-912423
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0070310	ATR-ATRIP complex	IPI	J:314777
Cellular Component	GO:0070310	ATR-ATRIP complex	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IDA	J:183982
Cellular Component	GO:0005694	chromosome	IDA	J:192634
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:284005
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912423
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912449
Cellular Component	GO:0005634	nucleus	NAS	J:314777
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	TAS	J:94951
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0001741	XY body	IDA	J:284005
Cellular Component	GO:0001741	XY body	IDA	J:131722
Biological Process	GO:0071480	cellular response to gamma radiation	ISO	J:164563
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0051276	chromosome organization	IMP	J:60768
Biological Process	GO:0000077	DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0000077	DNA damage checkpoint signaling	IBA	J:265628
Biological Process	GO:0000077	DNA damage checkpoint signaling	IMP	J:86382
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IDA	J:99862
Biological Process	GO:0006281	DNA repair	IDA	J:92518
Biological Process	GO:0007566	embryo implantation	IMP	J:60768
Biological Process	GO:0097694	establishment of RNA localization to telomere	ISO	J:164563
Biological Process	GO:0008156	negative regulation of DNA replication	ISO	J:164563
Biological Process	GO:0006139	nucleobase-containing compound metabolic process	NAS	J:320282
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:1904884	positive regulation of telomerase catalytic core complex assembly	ISO	J:164563
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	IMP	J:228143
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0070198	protein localization to chromosome, telomeric region	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:92518
Biological Process	GO:2000779	regulation of double-strand break repair	NAS	J:314777
Biological Process	GO:0043393	regulation of protein binding	IDA	J:99862
Biological Process	GO:0031297	replication fork processing	IMP	J:296112
Biological Process	GO:0090399	replicative senescence	ISO	J:164563
Biological Process	GO:0000723	telomere maintenance	IBA	J:265628