GO Annotations Graph

• Symbol: Siah1a
• Name: siah E3 ubiquitin protein ligase 1A
• ID: MGI:108064

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0097718	disordered domain specific binding	IPI	J:240284
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:82567
Molecular Function	GO:0005515	protein binding	IPI	J:159152
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:159152
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IMP	J:319952
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TAS	J:75489
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:73065
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:155856
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IDA	J:159152
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IDA	J:159152
Cellular Component	GO:0030877	beta-catenin destruction complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	IMP	J:240284
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0060070	canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:319952
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0007141	male meiosis I	IMP	J:75489
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0051402	neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0009791	post-embryonic development	IMP	J:75489
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	J:319952
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	J:159152
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0030163	protein catabolic process	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:155856
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:75489
Biological Process	GO:0007283	spermatogenesis	IMP	J:75489
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:155856
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:159152
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:73065