Nkx2-1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Nkx2-1
NK2 homeobox 1
MGI:108067

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	ISO	J:73065
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:217271
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:77089
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:145460
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:117072
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:74531
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:73065
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:73065
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:127637
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:27353
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	IDA	J:217271
Molecular Function	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	ISO	J:193977
Molecular Function	GO:0005515	protein binding	IPI	J:74531
Molecular Function	GO:0005515	protein binding	IPI	J:89484
Molecular Function	GO:0005515	protein binding	IPI	J:141842
Molecular Function	GO:0005515	protein binding	IPI	J:89484
Molecular Function	GO:0005515	protein binding	IPI	J:141842
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:211237
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:173973
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:193977
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:73065
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:77089
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:27353
Molecular Function	GO:0017025	TBP-class protein binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:141842
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:155856
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:155856
Molecular Function	GO:0008134	transcription factor binding	ISO	J:73065
Cellular Component	GO:0005654	nucleoplasm	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:217271
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:73657
Cellular Component	GO:0005634	nucleus	IDA	J:94299
Cellular Component	GO:0005634	nucleus	IDA	J:114501
Cellular Component	GO:0005634	nucleus	IDA	J:115581
Cellular Component	GO:0005634	nucleus	IDA	J:114501
Cellular Component	GO:0005634	nucleus	IDA	J:115581
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:248980
Cellular Component	GO:0005634	nucleus	IDA	J:144755
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:122531
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:115581
Cellular Component	GO:0005634	nucleus	IDA	J:144755
Cellular Component	GO:0005634	nucleus	IDA	J:111027
Cellular Component	GO:0005634	nucleus	IDA	J:27353
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:157830
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:85424
Cellular Component	GO:0005634	nucleus	IDA	J:173973
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:74531
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:117072
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:89484
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	IMP	J:122531
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:30559
Biological Process	GO:0007411	axon guidance	IMP	J:74238
Biological Process	GO:0007411	axon guidance	IMP	J:74238
Biological Process	GO:0007420	brain development	ISO	J:164563
Biological Process	GO:0007420	brain development	IMP	J:30559
Biological Process	GO:0007420	brain development	IGI	J:85473
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0021795	cerebral cortex cell migration	IMP	J:145460
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:145461
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:97012
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:145461
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:145461
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:97012
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:145461
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:97012
Biological Process	GO:0021895	cerebral cortex neuron differentiation	IMP	J:135983
Biological Process	GO:0021895	cerebral cortex neuron differentiation	IGI	J:135983
Biological Process	GO:0060486	club cell differentiation	IGI	J:117072
Biological Process	GO:0031128	developmental induction	IMP	J:50517
Biological Process	GO:0007492	endoderm development	IMP	J:30559
Biological Process	GO:0007492	endoderm development	IMP	J:54641
Biological Process	GO:0007631	feeding behavior	ISO	J:155856
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	IMP	J:55842
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	IMP	J:74238
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	IMP	J:66506
Biological Process	GO:0021879	forebrain neuron differentiation	IMP	J:66506
Biological Process	GO:0021879	forebrain neuron differentiation	IMP	J:66506
Biological Process	GO:0021877	forebrain neuron fate commitment	IGI	J:135983
Biological Process	GO:0021877	forebrain neuron fate commitment	IMP	J:135983
Biological Process	GO:0097154	GABAergic neuron differentiation	IMP	J:66506
Biological Process	GO:0010467	gene expression	IMP	J:295412
Biological Process	GO:0021759	globus pallidus development	ISO	J:164563
Biological Process	GO:0021759	globus pallidus development	IMP	J:157830
Biological Process	GO:0021766	hippocampus development	IMP	J:66506
Biological Process	GO:0042538	hyperosmotic salinity response	ISO	J:155856
Biological Process	GO:0021854	hypothalamus development	IMP	J:295412
Biological Process	GO:1904936	interneuron migration	IMP	J:145460
Biological Process	GO:1904936	interneuron migration	IMP	J:145460
Biological Process	GO:0033327	Leydig cell differentiation	IMP	J:80472
Biological Process	GO:0007626	locomotory behavior	IMP	J:74696
Biological Process	GO:0007626	locomotory behavior	ISO	J:73065
Biological Process	GO:0030324	lung development	IMP	J:60228
Biological Process	GO:0030324	lung development	IGI	J:171513
Biological Process	GO:0030324	lung development	IGI	J:171513
Biological Process	GO:0030324	lung development	IGI	J:171513
Biological Process	GO:0030324	lung development	ISO	J:73065
Biological Process	GO:0030324	lung development	IGI	J:171513
Biological Process	GO:0030324	lung development	IGI	J:171513
Biological Process	GO:0030324	lung development	IMP	J:85424
Biological Process	GO:0060430	lung saccule development	IGI	J:117072
Biological Process	GO:0042696	menarche	IMP	J:116686
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:211237
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:145460
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:193977
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048663	neuron fate commitment	IMP	J:145461
Biological Process	GO:0048663	neuron fate commitment	IMP	J:157830
Biological Process	GO:0001764	neuron migration	IMP	J:102348
Biological Process	GO:0048709	oligodendrocyte differentiation	IGI	J:67154
Biological Process	GO:0048709	oligodendrocyte differentiation	IGI	J:70747
Biological Process	GO:0007389	pattern specification process	IGI	J:85473
Biological Process	GO:0006644	phospholipid metabolic process	IGI	J:117072
Biological Process	GO:0021983	pituitary gland development	IMP	J:50517
Biological Process	GO:0021983	pituitary gland development	IMP	J:50517
Biological Process	GO:0042753	positive regulation of circadian rhythm	IMP	J:211237
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:211237
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:173003
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IGI	J:89484
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121284
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:114501
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:101308
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121284
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:114501
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:89484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121284
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117072
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:41061
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:114501
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:77089
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121221
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117072
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:127637
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:141842
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:114501
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:114501
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:27353
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:135983
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:160018
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:121221
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121284
Biological Process	GO:0002016	regulation of blood volume by renin-angiotensin	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:74531
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:141842
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0022029	telencephalon cell migration	IMP	J:145460
Biological Process	GO:0022029	telencephalon cell migration	IMP	J:157830
Biological Process	GO:0021537	telencephalon development	IMP	J:145461
Biological Process	GO:0030878	thyroid gland development	ISO	J:164563
Biological Process	GO:0030878	thyroid gland development	ISO	J:73065
Biological Process	GO:0030878	thyroid gland development	IMP	J:111027
Biological Process	GO:0030878	thyroid gland development	IMP	J:95017
Biological Process	GO:0030878	thyroid gland development	IGI	J:129685
Biological Process	GO:0060510	type II pneumocyte differentiation	IGI	J:117072

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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