GO Annotations Graph

• Symbol: Nkx2-1
• Name: NK2 homeobox 1
• ID: MGI:108067

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	ISO	J:73065
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:217271
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:77089
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:145460
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:117072
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:74531
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:73065
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:73065
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:127637
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:27353
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	IDA	J:217271
Molecular Function	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	ISO	J:193977
Molecular Function	GO:0005515	protein binding	IPI	J:74531
Molecular Function	GO:0005515	protein binding	IPI	J:89484
Molecular Function	GO:0005515	protein binding	IPI	J:141842
Molecular Function	GO:0005515	protein binding	IPI	J:89484
Molecular Function	GO:0005515	protein binding	IPI	J:141842
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:211237
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:173973
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:193977
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:73065
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:77089
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:27353
Molecular Function	GO:0017025	TBP-class protein binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:141842
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:155856
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:155856
Molecular Function	GO:0008134	transcription factor binding	ISO	J:73065
Cellular Component	GO:0005654	nucleoplasm	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:217271
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:73657
Cellular Component	GO:0005634	nucleus	IDA	J:94299
Cellular Component	GO:0005634	nucleus	IDA	J:114501
Cellular Component	GO:0005634	nucleus	IDA	J:115581
Cellular Component	GO:0005634	nucleus	IDA	J:114501
Cellular Component	GO:0005634	nucleus	IDA	J:115581
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:248980
Cellular Component	GO:0005634	nucleus	IDA	J:144755
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:122531
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005634	nucleus	IDA	J:115581
Cellular Component	GO:0005634	nucleus	IDA	J:144755
Cellular Component	GO:0005634	nucleus	IDA	J:111027
Cellular Component	GO:0005634	nucleus	IDA	J:27353
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:157830
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:85424
Cellular Component	GO:0005634	nucleus	IDA	J:173973
Cellular Component	GO:0005634	nucleus	IDA	J:35560
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:74531
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:117072
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:89484
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	IMP	J:122531
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:30559
Biological Process	GO:0007411	axon guidance	IMP	J:74238
Biological Process	GO:0007411	axon guidance	IMP	J:74238
Biological Process	GO:0007420	brain development	ISO	J:164563
Biological Process	GO:0007420	brain development	IMP	J:30559
Biological Process	GO:0007420	brain development	IGI	J:85473
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0021795	cerebral cortex cell migration	IMP	J:145460
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:145461
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:97012
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:145461
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:145461
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:97012
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:145461
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	IMP	J:97012
Biological Process	GO:0021895	cerebral cortex neuron differentiation	IMP	J:135983
Biological Process	GO:0021895	cerebral cortex neuron differentiation	IGI	J:135983
Biological Process	GO:0060486	club cell differentiation	IGI	J:117072
Biological Process	GO:0031128	developmental induction	IMP	J:50517
Biological Process	GO:0007492	endoderm development	IMP	J:30559
Biological Process	GO:0007492	endoderm development	IMP	J:54641
Biological Process	GO:0007631	feeding behavior	ISO	J:155856
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	IMP	J:55842
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	IMP	J:74238
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	IMP	J:66506
Biological Process	GO:0021879	forebrain neuron differentiation	IMP	J:66506
Biological Process	GO:0021879	forebrain neuron differentiation	IMP	J:66506
Biological Process	GO:0021877	forebrain neuron fate commitment	IGI	J:135983
Biological Process	GO:0021877	forebrain neuron fate commitment	IMP	J:135983
Biological Process	GO:0097154	GABAergic neuron differentiation	IMP	J:66506
Biological Process	GO:0010467	gene expression	IMP	J:295412
Biological Process	GO:0021759	globus pallidus development	ISO	J:164563
Biological Process	GO:0021759	globus pallidus development	IMP	J:157830
Biological Process	GO:0021766	hippocampus development	IMP	J:66506
Biological Process	GO:0042538	hyperosmotic salinity response	ISO	J:155856
Biological Process	GO:0021854	hypothalamus development	IMP	J:295412
Biological Process	GO:1904936	interneuron migration	IMP	J:145460
Biological Process	GO:1904936	interneuron migration	IMP	J:145460
Biological Process	GO:0033327	Leydig cell differentiation	IMP	J:80472
Biological Process	GO:0007626	locomotory behavior	IMP	J:74696
Biological Process	GO:0007626	locomotory behavior	ISO	J:73065
Biological Process	GO:0030324	lung development	IMP	J:60228
Biological Process	GO:0030324	lung development	IGI	J:171513
Biological Process	GO:0030324	lung development	IGI	J:171513
Biological Process	GO:0030324	lung development	IGI	J:171513
Biological Process	GO:0030324	lung development	ISO	J:73065
Biological Process	GO:0030324	lung development	IGI	J:171513
Biological Process	GO:0030324	lung development	IGI	J:171513
Biological Process	GO:0030324	lung development	IMP	J:85424
Biological Process	GO:0060430	lung saccule development	IGI	J:117072
Biological Process	GO:0042696	menarche	IMP	J:116686
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:211237
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:145460
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:193977
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048663	neuron fate commitment	IMP	J:145461
Biological Process	GO:0048663	neuron fate commitment	IMP	J:157830
Biological Process	GO:0001764	neuron migration	IMP	J:102348
Biological Process	GO:0048709	oligodendrocyte differentiation	IGI	J:67154
Biological Process	GO:0048709	oligodendrocyte differentiation	IGI	J:70747
Biological Process	GO:0007389	pattern specification process	IGI	J:85473
Biological Process	GO:0006644	phospholipid metabolic process	IGI	J:117072
Biological Process	GO:0021983	pituitary gland development	IMP	J:50517
Biological Process	GO:0021983	pituitary gland development	IMP	J:50517
Biological Process	GO:0042753	positive regulation of circadian rhythm	IMP	J:211237
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:211237
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:173003
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IGI	J:89484
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121284
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:114501
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:101308
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121284
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:114501
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:89484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121284
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117072
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:41061
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:114501
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:77089
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121221
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117072
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:127637
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:141842
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:114501
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:114501
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121211
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:27353
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:135983
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:160018
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:121221
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121284
Biological Process	GO:0002016	regulation of blood volume by renin-angiotensin	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:74531
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:141842
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0022029	telencephalon cell migration	IMP	J:145460
Biological Process	GO:0022029	telencephalon cell migration	IMP	J:157830
Biological Process	GO:0021537	telencephalon development	IMP	J:145461
Biological Process	GO:0030878	thyroid gland development	ISO	J:164563
Biological Process	GO:0030878	thyroid gland development	ISO	J:73065
Biological Process	GO:0030878	thyroid gland development	IMP	J:111027
Biological Process	GO:0030878	thyroid gland development	IMP	J:95017
Biological Process	GO:0030878	thyroid gland development	IGI	J:129685
Biological Process	GO:0060510	type II pneumocyte differentiation	IGI	J:117072