GO Annotations Graph

• Symbol: Hpgd
• Name: hydroxyprostaglandin dehydrogenase 15 (NAD)
• ID: MGI:108085

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0047034	15-hydroxyicosatetraenoate dehydrogenase activity	IEA	J:72245
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	ISO	J:155856
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	ISO	J:164563
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IBA	J:265628
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IDA	J:105183
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0051287	NAD binding	ISO	J:164563
Molecular Function	GO:0070403	NAD+ binding	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISO	J:164563
Molecular Function	GO:0004957	prostaglandin E receptor activity	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:165322
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Biological Process	GO:0097070	ductus arteriosus closure	IMP	J:74466
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0007565	female pregnancy	ISO	J:164563
Biological Process	GO:0007565	female pregnancy	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0045786	negative regulation of cell cycle	ISO	J:164563
Biological Process	GO:0007567	parturition	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0006693	prostaglandin metabolic process	ISO	J:155856
Biological Process	GO:0006693	prostaglandin metabolic process	ISO	J:164563
Biological Process	GO:0006693	prostaglandin metabolic process	IBA	J:265628
Biological Process	GO:1905828	regulation of prostaglandin catabolic process	ISO	J:164563
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563