GO Annotations Graph

• Symbol: Hdac1
• Name: histone deacetylase 1
• ID: MGI:108086

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	IDA	J:104056
Molecular Function	GO:0003682	chromatin binding	IDA	J:121427
Molecular Function	GO:0003682	chromatin binding	IDA	J:96437
Molecular Function	GO:0003682	chromatin binding	IDA	J:114817
Molecular Function	GO:0003682	chromatin binding	IDA	J:130039
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0019213	deacetylase activity	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IDA	J:86311
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	TAS	J:113927
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:305429
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:219094
Molecular Function	GO:0070888	E-box binding	IDA	J:209571
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0004407	histone deacetylase activity	IDA	J:319948
Molecular Function	GO:0004407	histone deacetylase activity	IDA	J:113866
Molecular Function	GO:0004407	histone deacetylase activity	ISO	J:155856
Molecular Function	GO:0004407	histone deacetylase activity	IDA	J:176119
Molecular Function	GO:0004407	histone deacetylase activity	ISO	J:164563
Molecular Function	GO:0004407	histone deacetylase activity	TAS	Reactome:R-MMU-573376
Molecular Function	GO:0004407	histone deacetylase activity	IBA	J:265628
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0160009	histone decrotonylase activity	ISO	J:164563
Molecular Function	GO:0160009	histone decrotonylase activity	IDA	J:319948
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0035851	Krueppel-associated box domain binding	IPI	J:203400
Molecular Function	GO:0051059	NF-kappaB binding	ISO	J:164563
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:227373
Molecular Function	GO:0005515	protein binding	IPI	J:319940
Molecular Function	GO:0005515	protein binding	IPI	J:322384
Molecular Function	GO:0005515	protein binding	IPI	J:171270
Molecular Function	GO:0005515	protein binding	IPI	J:100129
Molecular Function	GO:0005515	protein binding	IPI	J:227377
Molecular Function	GO:0005515	protein binding	IPI	J:217995
Molecular Function	GO:0005515	protein binding	IPI	J:210023
Molecular Function	GO:0005515	protein binding	IPI	J:114110
Molecular Function	GO:0005515	protein binding	IPI	J:144189
Molecular Function	GO:0005515	protein binding	IPI	J:282485
Molecular Function	GO:0005515	protein binding	IPI	J:243422
Molecular Function	GO:0005515	protein binding	IPI	J:114110
Molecular Function	GO:0005515	protein binding	IPI	J:209491
Molecular Function	GO:0005515	protein binding	IPI	J:169899
Molecular Function	GO:0005515	protein binding	IPI	J:177242
Molecular Function	GO:0005515	protein binding	IPI	J:207814
Molecular Function	GO:0005515	protein binding	IPI	J:190264
Molecular Function	GO:0005515	protein binding	IPI	J:176119
Molecular Function	GO:0005515	protein binding	IPI	J:113974
Molecular Function	GO:0005515	protein binding	IPI	J:236647
Molecular Function	GO:0005515	protein binding	IPI	J:160317
Molecular Function	GO:0005515	protein binding	IPI	J:98945
Molecular Function	GO:0005515	protein binding	IPI	J:245247
Molecular Function	GO:0005515	protein binding	IPI	J:209571
Molecular Function	GO:0005515	protein binding	IPI	J:150926
Molecular Function	GO:0005515	protein binding	IPI	J:113866
Molecular Function	GO:0005515	protein binding	IPI	J:272747
Molecular Function	GO:0005515	protein binding	IPI	J:162637
Molecular Function	GO:0005515	protein binding	IPI	J:200299
Molecular Function	GO:0005515	protein binding	IPI	J:182157
Molecular Function	GO:0005515	protein binding	IPI	J:150066
Molecular Function	GO:0005515	protein binding	IPI	J:319689
Molecular Function	GO:0005515	protein binding	IPI	J:206161
Molecular Function	GO:0005515	protein binding	IPI	J:245310
Molecular Function	GO:0005515	protein binding	IPI	J:203400
Molecular Function	GO:0005515	protein binding	IPI	J:148391
Molecular Function	GO:0005515	protein binding	IPI	J:81640
Molecular Function	GO:0005515	protein binding	IPI	J:104074
Molecular Function	GO:0005515	protein binding	IPI	J:87046
Molecular Function	GO:0005515	protein binding	IPI	J:185774
Molecular Function	GO:0005515	protein binding	IPI	J:104056
Molecular Function	GO:0005515	protein binding	IPI	J:76167
Molecular Function	GO:0005515	protein binding	IPI	J:212358
Molecular Function	GO:0005515	protein binding	IPI	J:72326
Molecular Function	GO:0005515	protein binding	IPI	J:150656
Molecular Function	GO:0005515	protein binding	IPI	J:106974
Molecular Function	GO:0005515	protein binding	IPI	J:76167
Molecular Function	GO:0005515	protein binding	IPI	J:185774
Molecular Function	GO:0005515	protein binding	IPI	J:87046
Molecular Function	GO:0005515	protein binding	IPI	J:106974
Molecular Function	GO:0005515	protein binding	IPI	J:178818
Molecular Function	GO:0005515	protein binding	IPI	J:104056
Molecular Function	GO:0005515	protein binding	IPI	J:154112
Molecular Function	GO:0005515	protein binding	IPI	J:84664
Molecular Function	GO:0005515	protein binding	IPI	J:106974
Molecular Function	GO:0005515	protein binding	IPI	J:76167
Molecular Function	GO:0005515	protein binding	IPI	J:36570
Molecular Function	GO:0005515	protein binding	IPI	J:154112
Molecular Function	GO:0005515	protein binding	IPI	J:40055
Molecular Function	GO:0005515	protein binding	IPI	J:123041
Molecular Function	GO:0005515	protein binding	IPI	J:132209
Molecular Function	GO:0005515	protein binding	IPI	J:76167
Molecular Function	GO:0005515	protein binding	IPI	J:152576
Molecular Function	GO:0005515	protein binding	IPI	J:87046
Molecular Function	GO:0005515	protein binding	IPI	J:84664
Molecular Function	GO:0005515	protein binding	IPI	J:76167
Molecular Function	GO:0005515	protein binding	IPI	J:104074
Molecular Function	GO:0005515	protein binding	IPI	J:76212
Molecular Function	GO:0005515	protein binding	IPI	J:94611
Molecular Function	GO:0005515	protein binding	IPI	J:145836
Molecular Function	GO:0005515	protein binding	IPI	J:227373
Molecular Function	GO:0033558	protein lysine deacetylase activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:146223
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:210023
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:36570
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:94611
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:168590
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	TAS	J:113927
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0000792	heterochromatin	IDA	J:86777
Cellular Component	GO:0000792	heterochromatin	IDA	J:86958
Cellular Component	GO:0000792	heterochromatin	IDA	J:86958
Cellular Component	GO:0000118	histone deacetylase complex	ISO	J:164563
Cellular Component	GO:0000118	histone deacetylase complex	TAS	J:113927
Cellular Component	GO:0000118	histone deacetylase complex	IPI	J:87046
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IDA	J:139010
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-573336
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-573376
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-573383
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8978954
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8978970
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8978980
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8978989
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9006133
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9017958
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9625109
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-573373
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-573385
Cellular Component	GO:0005634	nucleus	NAS	J:243422
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:227373
Cellular Component	GO:0005634	nucleus	IDA	J:176455
Cellular Component	GO:0005634	nucleus	IDA	J:132209
Cellular Component	GO:0005634	nucleus	IDA	J:168362
Cellular Component	GO:0016581	NuRD complex	NAS	J:319987
Cellular Component	GO:0016581	NuRD complex	ISO	J:164563
Cellular Component	GO:0016581	NuRD complex	IBA	J:265628
Cellular Component	GO:0016581	NuRD complex	IPI	J:106974
Cellular Component	GO:0016581	NuRD complex	IDA	J:185774
Cellular Component	GO:0016581	NuRD complex	IDA	J:76167
Cellular Component	GO:0016581	NuRD complex	IPI	J:106974
Cellular Component	GO:0016581	NuRD complex	IPI	J:106974
Cellular Component	GO:0016581	NuRD complex	IPI	J:87046
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	IDA	J:154112
Cellular Component	GO:0016580	Sin3 complex	NAS	J:243422
Cellular Component	GO:0016580	Sin3 complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:175166
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:123890
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:123890
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:123890
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:123890
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:123890
Cellular Component	GO:0017053	transcription repressor complex	IPI	J:123890
Cellular Component	GO:0017053	transcription repressor complex	IPI	J:123890
Cellular Component	GO:0017053	transcription repressor complex	IPI	J:123890
Cellular Component	GO:0017053	transcription repressor complex	IPI	J:123890
Cellular Component	GO:0017053	transcription repressor complex	IPI	J:123890
Biological Process	GO:0006325	chromatin organization	TAS	J:113927
Biological Process	GO:0006338	chromatin remodeling	ISO	J:164563
Biological Process	GO:0032922	circadian regulation of gene expression	IDA	J:209491
Biological Process	GO:0007623	circadian rhythm	IDA	J:209571
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	ISO	J:164563
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:168590
Biological Process	GO:0007492	endoderm development	IMP	J:89931
Biological Process	GO:0007492	endoderm development	IDA	J:89931
Biological Process	GO:0009913	epidermal cell differentiation	IGI	J:168590
Biological Process	GO:0061029	eyelid development in camera-type eye	IGI	J:168590
Biological Process	GO:0061198	fungiform papilla formation	IGI	J:168590
Biological Process	GO:0060789	hair follicle placode formation	IGI	J:168590
Biological Process	GO:0021766	hippocampus development	IGI	J:148408
Biological Process	GO:0016575	histone deacetylation	ISO	J:164563
Biological Process	GO:0016575	histone deacetylation	IBA	J:265628
Biological Process	GO:0070932	histone H3 deacetylation	ISO	J:164563
Biological Process	GO:0070933	histone H4 deacetylation	ISO	J:164563
Biological Process	GO:0043922	negative regulation by host of viral transcription	ISO	J:164563
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IGI	J:168590
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:152576
Biological Process	GO:0030336	negative regulation of cell migration	NAS	J:320045
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:176119
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NAS	J:319679
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:42359
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:153689
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	IGI	J:168590
Biological Process	GO:1902455	negative regulation of stem cell population maintenance	NAS	J:243422
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NAS	J:320044
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:168590
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NAS	J:320043
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:42359
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:36570
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	NAS	J:320045
Biological Process	GO:0030182	neuron differentiation	IGI	J:148408
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IGI	J:168590
Biological Process	GO:0048709	oligodendrocyte differentiation	IGI	J:152576
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:168590
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NAS	J:156393
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IGI	J:152576
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IGI	J:152576
Biological Process	GO:2000273	positive regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:1902459	positive regulation of stem cell population maintenance	NAS	J:243422
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	ISO	J:164563
Biological Process	GO:0042659	regulation of cell fate specification	NAS	J:319679
Biological Process	GO:0052548	regulation of endopeptidase activity	ISO	J:164563
Biological Process	GO:2000736	regulation of stem cell differentiation	NAS	J:319679
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0048511	rhythmic process	IEA	J:60000