GO Annotations Graph

• Symbol: Bin1
• Name: bridging integrator 1
• ID: MGI:108092

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	IMP	J:237310
Molecular Function	GO:0051020	GTPase binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005543	phospholipid binding	IBA	J:265628
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:203880
Molecular Function	GO:0005515	protein binding	IPI	J:201933
Molecular Function	GO:0005515	protein binding	IPI	J:35155
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0070063	RNA polymerase binding	ISO	J:164563
Molecular Function	GO:0048156	tau protein binding	ISO	J:164563
Molecular Function	GO:0048156	tau protein binding	IPI	J:201933
Molecular Function	GO:0048156	tau protein binding	ISO	J:164563
Molecular Function	GO:0048156	tau protein binding	IBA	J:265628
Cellular Component	GO:0030424	axon	ISO	J:164563
Cellular Component	GO:0030424	axon	IDA	J:297331
Cellular Component	GO:0043194	axon initial segment	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0044300	cerebellar mossy fiber	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IDA	J:297331
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0098850	extrinsic component of synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:75306
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:75306
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:75306
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:75306
Cellular Component	GO:0031674	I band	ISO	J:155856
Cellular Component	GO:0060987	lipid tube	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0033268	node of Ranvier	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	IDA	J:231236
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:35155
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0090571	RNA polymerase II transcription repressor complex	ISO	J:164563
Cellular Component	GO:0045202	synapse	IDA	J:263386
Cellular Component	GO:0045202	synapse	EXP	J:263386
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	IBA	J:265628
Cellular Component	GO:0030315	T-tubule	IDA	J:213224
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0043196	varicosity	ISO	J:155856
Cellular Component	GO:0031982	vesicle	IDA	J:297331
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0008333	endosome to lysosome transport	ISO	J:164563
Biological Process	GO:0060988	lipid tube assembly	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0042692	muscle cell differentiation	IMP	J:53316
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	IMP	J:237310
Biological Process	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IMP	J:237310
Biological Process	GO:1904878	negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IMP	J:213224
Biological Process	GO:1901380	negative regulation of potassium ion transmembrane transport	IMP	J:213224
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:1903946	negative regulation of ventricular cardiac muscle cell action potential	IMP	J:213224
Biological Process	GO:0051647	nucleus localization	IMP	J:231236
Biological Process	GO:0006997	nucleus organization	ISO	J:164563
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IDA	J:213224
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	ISO	J:164563
Biological Process	GO:0045807	positive regulation of endocytosis	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:155856
Biological Process	GO:0010564	regulation of cell cycle process	ISO	J:164563
Biological Process	GO:0030100	regulation of endocytosis	IEA	J:72247
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:213224
Biological Process	GO:0045664	regulation of neuron differentiation	ISO	J:164563
Biological Process	GO:0048488	synaptic vesicle endocytosis	ISO	J:155856
Biological Process	GO:0048488	synaptic vesicle endocytosis	IMP	J:75306
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:75306
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:75306
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:75306
Biological Process	GO:0048488	synaptic vesicle endocytosis	IMP	J:75306
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:75306
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:75306
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:75306
Biological Process	GO:0033292	T-tubule organization	ISO	J:164563
Biological Process	GO:0033292	T-tubule organization	IMP	J:213224