GO Annotations Graph

• Symbol: Slc22a1
• Name: solute carrier family 22 (organic cation transporter), member 1
• ID: MGI:108111

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1901235	(R)-carnitine transmembrane transporter activity	IDA	J:331913
Molecular Function	GO:1901235	(R)-carnitine transmembrane transporter activity	IDA	J:258547
Molecular Function	GO:0005277	acetylcholine transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0005277	acetylcholine transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0005330	dopamine:sodium symporter activity	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	IDA	J:331920
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	IDA	J:212164
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	IDA	J:212164
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	IDA	J:331920
Molecular Function	GO:0005334	norepinephrine:sodium symporter activity	ISO	J:155856
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	IDA	J:78891
Molecular Function	GO:0015132	prostaglandin transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0015489	putrescine transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0015214	pyrimidine nucleoside transmembrane transporter activity	IMP	J:289092
Molecular Function	GO:0015214	pyrimidine nucleoside transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	IDA	J:331920
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0008513	secondary active organic cation transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0015606	spermidine transmembrane transporter activity	IDA	J:331353
Molecular Function	GO:0015234	thiamine transmembrane transporter activity	IDA	J:212164
Molecular Function	GO:0015234	thiamine transmembrane transporter activity	IDA	J:331920
Molecular Function	GO:0019534	toxin transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0019534	toxin transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0019534	toxin transmembrane transporter activity	IMP	J:289092
Molecular Function	GO:0022857	transmembrane transporter activity	IEA	J:72247
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	IDA	J:70604
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	IMP	J:289092
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:331354
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:289092
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:258547
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0016328	lateral plasma membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:78891
Biological Process	GO:1902270	(R)-carnitine transmembrane transport	IDA	J:258547
Biological Process	GO:1902270	(R)-carnitine transmembrane transport	IDA	J:331913
Biological Process	GO:0015870	acetylcholine transport	ISO	J:164563
Biological Process	GO:1902616	acyl carnitine transmembrane transport	IDA	J:258547
Biological Process	GO:1902616	acyl carnitine transmembrane transport	IDA	J:331913
Biological Process	GO:0015872	dopamine transport	ISO	J:155856
Biological Process	GO:0015872	dopamine transport	IDA	J:331920
Biological Process	GO:0015872	dopamine transport	ISO	J:164563
Biological Process	GO:0090494	dopamine uptake	ISO	J:164563
Biological Process	GO:0048241	epinephrine transport	IDA	J:331920
Biological Process	GO:0048241	epinephrine transport	ISO	J:164563
Biological Process	GO:0048241	epinephrine transport	ISO	J:155856
Biological Process	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	ISO	J:155856
Biological Process	GO:0015844	monoamine transport	ISO	J:164563
Biological Process	GO:0015844	monoamine transport	IDA	J:331920
Biological Process	GO:0015844	monoamine transport	ISO	J:155856
Biological Process	GO:0098655	monoatomic cation transmembrane transport	ISO	J:155856
Biological Process	GO:0006812	monoatomic cation transport	IDA	J:78891
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006836	neurotransmitter transport	ISO	J:164563
Biological Process	GO:0015874	norepinephrine transport	IDA	J:331920
Biological Process	GO:0015874	norepinephrine transport	ISO	J:164563
Biological Process	GO:0015874	norepinephrine transport	ISO	J:155856
Biological Process	GO:0015695	organic cation transport	ISO	J:155856
Biological Process	GO:0015695	organic cation transport	IDA	J:78891
Biological Process	GO:0015695	organic cation transport	ISO	J:164563
Biological Process	GO:0015695	organic cation transport	IBA	J:265628
Biological Process	GO:0015732	prostaglandin transport	ISO	J:164563
Biological Process	GO:0015847	putrescine transport	ISO	J:164563
Biological Process	GO:0015697	quaternary ammonium group transport	ISO	J:164563
Biological Process	GO:0015697	quaternary ammonium group transport	ISO	J:155856
Biological Process	GO:0006837	serotonin transport	IDA	J:212164
Biological Process	GO:0006837	serotonin transport	IDA	J:331920
Biological Process	GO:0006837	serotonin transport	ISO	J:155856
Biological Process	GO:0006837	serotonin transport	ISO	J:164563
Biological Process	GO:0051610	serotonin uptake	ISO	J:164563
Biological Process	GO:0015848	spermidine transport	IDA	J:331353
Biological Process	GO:0071934	thiamine transmembrane transport	IDA	J:212164
Biological Process	GO:0071934	thiamine transmembrane transport	ISO	J:164563
Biological Process	GO:0071934	thiamine transmembrane transport	IDA	J:331920
Biological Process	GO:0015888	thiamine transport	ISO	J:164563
Biological Process	GO:1901998	toxin transport	ISO	J:155856
Biological Process	GO:1901998	toxin transport	IMP	J:289092
Biological Process	GO:1901998	toxin transport	ISO	J:164563
Biological Process	GO:0055085	transmembrane transport	IDA	J:78891
Biological Process	GO:0042908	xenobiotic transport	ISO	J:164563
Biological Process	GO:0042908	xenobiotic transport	IDA	J:70604
Biological Process	GO:0042908	xenobiotic transport	IMP	J:289092
Biological Process	GO:0042908	xenobiotic transport	ISO	J:155856
Biological Process	GO:1990962	xenobiotic transport across blood-brain barrier	NAS	J:289092