GO Annotations Graph

• Symbol: Ripk1
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
• ID: MGI:108212

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0070513	death domain binding	ISO	J:164563
Molecular Function	GO:0005123	death receptor binding	ISO	J:164563
Molecular Function	GO:0005123	death receptor binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:209137
Molecular Function	GO:0005515	protein binding	IPI	J:200442
Molecular Function	GO:0005515	protein binding	IPI	J:187699
Molecular Function	GO:0005515	protein binding	IPI	J:131809
Molecular Function	GO:0005515	protein binding	IPI	J:248272
Molecular Function	GO:0005515	protein binding	IPI	J:281166
Molecular Function	GO:0005515	protein binding	IPI	J:180557
Molecular Function	GO:0005515	protein binding	IPI	J:138824
Molecular Function	GO:0005515	protein binding	IPI	J:263339
Molecular Function	GO:0005515	protein binding	IPI	J:279494
Molecular Function	GO:0005515	protein binding	IPI	J:228302
Molecular Function	GO:0005515	protein binding	IPI	J:170814
Molecular Function	GO:0005515	protein binding	IPI	J:182381
Molecular Function	GO:0005515	protein binding	IPI	J:265780
Molecular Function	GO:0005515	protein binding	IPI	J:251915
Molecular Function	GO:0005515	protein binding	IPI	J:201253
Molecular Function	GO:0005515	protein binding	IPI	J:152731
Molecular Function	GO:0005515	protein binding	IPI	J:226752
Molecular Function	GO:0005515	protein binding	IPI	J:128397
Molecular Function	GO:0005515	protein binding	IPI	J:128397
Molecular Function	GO:0005515	protein binding	IPI	J:205986
Molecular Function	GO:0005515	protein binding	IPI	J:128397
Molecular Function	GO:0005515	protein binding	IPI	J:152781
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:265780
Molecular Function	GO:0004672	protein kinase activity	IMP	J:265780
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:89527
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:244164
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:275558
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:285926
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:279494
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:242990
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:281166
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:281456
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0031264	death-inducing signaling complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0097342	ripoptosome	ISO	J:164563
Biological Process	GO:1990000	amyloid fibril formation	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IMP	J:281166
Biological Process	GO:0006915	apoptotic process	IMP	J:280188
Biological Process	GO:0006915	apoptotic process	IMP	J:251915
Biological Process	GO:0006915	apoptotic process	IMP	J:279494
Biological Process	GO:0006915	apoptotic process	IMP	J:265780
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IMP	J:281456
Biological Process	GO:0008219	cell death	IMP	J:275558
Biological Process	GO:0008219	cell death	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IMP	J:180557
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IMP	J:259866
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0070266	necroptotic process	IMP	J:280188
Biological Process	GO:0070266	necroptotic process	IDA	J:244164
Biological Process	GO:0070266	necroptotic process	IMP	J:251915
Biological Process	GO:0070266	necroptotic process	ISO	J:164563
Biological Process	GO:0070266	necroptotic process	IMP	J:279494
Biological Process	GO:0070266	necroptotic process	IMP	J:281166
Biological Process	GO:0070266	necroptotic process	IMP	J:265780
Biological Process	GO:0070266	necroptotic process	IGI	J:180684
Biological Process	GO:0070266	necroptotic process	IGI	J:180684
Biological Process	GO:0070266	necroptotic process	IGI	J:182381
Biological Process	GO:0070266	necroptotic process	IGI	J:200967
Biological Process	GO:0070266	necroptotic process	IGI	J:182381
Biological Process	GO:0070266	necroptotic process	IGI	J:200967
Biological Process	GO:0097527	necroptotic signaling pathway	IMP	J:176448
Biological Process	GO:0097527	necroptotic signaling pathway	IMP	J:285926
Biological Process	GO:0097527	necroptotic signaling pathway	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:242990
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:281201
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:214394
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:214393
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IGI	J:202809
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IGI	J:202809
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:180557
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0060546	negative regulation of necroptotic process	IMP	J:242990
Biological Process	GO:0060546	negative regulation of necroptotic process	IMP	J:214393
Biological Process	GO:0060546	negative regulation of necroptotic process	IMP	J:242991
Biological Process	GO:0060546	negative regulation of necroptotic process	IMP	J:214394
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	ISO	J:164563
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	IMP	J:285926
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IGI	J:200967
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:1905206	positive regulation of hydrogen peroxide-induced cell death	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:202809
Biological Process	GO:0050729	positive regulation of inflammatory response	IMP	J:285926
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0070105	positive regulation of interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070105	positive regulation of interleukin-6-mediated signaling pathway	IMP	J:285926
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:180557
Biological Process	GO:0045651	positive regulation of macrophage differentiation	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:180557
Biological Process	GO:0060545	positive regulation of necroptotic process	ISO	J:155856
Biological Process	GO:0060545	positive regulation of necroptotic process	ISO	J:164563
Biological Process	GO:0010940	positive regulation of necrotic cell death	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:180557
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:279494
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:281166
Biological Process	GO:0042327	positive regulation of phosphorylation	IMP	J:182381
Biological Process	GO:0043068	positive regulation of programmed cell death	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0051347	positive regulation of transferase activity	IGI	J:200967
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	IDA	J:268016
Biological Process	GO:0012501	programmed cell death	IEA	J:60000
Biological Process	GO:0097300	programmed necrotic cell death	IMP	J:259866
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IMP	J:275558
Biological Process	GO:0046777	protein autophosphorylation	IMP	J:265780
Biological Process	GO:0030163	protein catabolic process	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0070926	regulation of ATP:ADP antiporter activity	ISO	J:164563
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	IMP	J:182381
Biological Process	GO:0034612	response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0097343	ripoptosome assembly	ISO	J:164563
Biological Process	GO:1901026	ripoptosome assembly involved in necroptotic process	IGI	J:182381
Biological Process	GO:1901026	ripoptosome assembly involved in necroptotic process	IGI	J:182381
Biological Process	GO:1901026	ripoptosome assembly involved in necroptotic process	IGI	J:182381
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0070231	T cell apoptotic process	IMP	J:176448