GO Annotations Graph

• Symbol: Ccl12
• Name: C-C motif chemokine ligand 12
• ID: MGI:108224

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048020	CCR chemokine receptor binding	IBA	J:265628
Molecular Function	GO:0031727	CCR2 chemokine receptor binding	IPI	J:37573
Molecular Function	GO:0008009	chemokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IDA	J:169885
Biological Process	GO:0043615	astrocyte cell migration	ISO	J:164563
Biological Process	GO:0071347	cellular response to interleukin-1	IBA	J:265628
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IBA	J:265628
Biological Process	GO:0071346	cellular response to type II interferon	IBA	J:265628
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007010	cytoskeleton organization	ISO	J:164563
Biological Process	GO:0048245	eosinophil chemotaxis	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IDA	J:37573
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0048247	lymphocyte chemotaxis	IBA	J:265628
Biological Process	GO:0048246	macrophage chemotaxis	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0002548	monocyte chemotaxis	IDA	J:37573
Biological Process	GO:0002548	monocyte chemotaxis	ISO	J:164563
Biological Process	GO:0002548	monocyte chemotaxis	IBA	J:265628
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	ISO	J:164563
Biological Process	GO:0070664	negative regulation of leukocyte proliferation	ISO	J:155856
Biological Process	GO:2000502	negative regulation of natural killer cell chemotaxis	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0090280	positive regulation of calcium ion import	ISO	J:164563
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0002687	positive regulation of leukocyte migration	ISO	J:155856
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563