GO Annotations Graph

• Symbol: Tdg
• Name: thymine DNA glycosylase
• ID: MGI:108247

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0031404	chloride ion binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:175857
Molecular Function	GO:0019104	DNA N-glycosylase activity	IDA	J:175857
Molecular Function	GO:0019104	DNA N-glycosylase activity	IDA	J:174772
Molecular Function	GO:0019104	DNA N-glycosylase activity	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0043739	G/U mismatch-specific uracil-DNA glycosylase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0000700	mismatch base pair DNA N-glycosylase activity	IEA	J:72247
Molecular Function	GO:0030983	mismatched DNA binding	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:103776
Molecular Function	GO:0005515	protein binding	IPI	J:144638
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	IPI	J:173008
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	ISO	J:164563
Molecular Function	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	IBA	J:265628
Molecular Function	GO:0031402	sodium ion binding	ISO	J:164563
Molecular Function	GO:0032183	SUMO binding	ISO	J:164563
Molecular Function	GO:0032183	SUMO binding	IPI	J:96947
Molecular Function	GO:0003712	transcription coregulator activity	IGI	J:144638
Molecular Function	GO:0003712	transcription coregulator activity	IGI	J:144638
Molecular Function	GO:0003712	transcription coregulator activity	IGI	J:144638
Molecular Function	GO:0004844	uracil DNA N-glycosylase activity	ISO	J:164563
Molecular Function	GO:0004844	uracil DNA N-glycosylase activity	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:173008
Cellular Component	GO:0005634	nucleus	IDA	J:96947
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0016605	PML body	IDA	J:96947
Biological Process	GO:0006284	base-excision repair	ISO	J:164563
Biological Process	GO:0006284	base-excision repair	IDA	J:175857
Biological Process	GO:0006285	base-excision repair, AP site formation	ISO	J:164563
Biological Process	GO:0006285	base-excision repair, AP site formation	IBA	J:265628
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0080111	DNA demethylation	IMP	J:196259
Biological Process	GO:0080111	DNA demethylation	IDA	J:175857
Biological Process	GO:0080111	DNA demethylation	IMP	J:174772
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0040029	epigenetic regulation of gene expression	IMP	J:174772
Biological Process	GO:0040029	epigenetic regulation of gene expression	IMP	J:196259
Biological Process	GO:0006298	mismatch repair	ISO	J:164563
Biological Process	GO:0035562	negative regulation of chromatin binding	IDA	J:144638
Biological Process	GO:0032091	negative regulation of protein binding	IDA	J:144638
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144638
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144638
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:144638
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144638
Biological Process	GO:1902544	regulation of DNA N-glycosylase activity	ISO	J:164563
Biological Process	GO:0045995	regulation of embryonic development	IMP	J:196259
Biological Process	GO:0045995	regulation of embryonic development	IMP	J:174772