GO Annotations Graph

• Symbol: Pxn
• Name: paxillin
• ID: MGI:108295

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0051435	BH4 domain binding	IPI	J:88736
Molecular Function	GO:0051435	BH4 domain binding	IPI	J:88736
Molecular Function	GO:0051435	BH4 domain binding	IPI	J:88736
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0005078	MAP-kinase scaffold activity	IDA	J:86622
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0038191	neuropilin binding	IPI	J:214295
Molecular Function	GO:0038191	neuropilin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:273522
Molecular Function	GO:0005515	protein binding	IPI	J:200352
Molecular Function	GO:0005515	protein binding	IPI	J:136695
Molecular Function	GO:0005515	protein binding	IPI	J:116386
Molecular Function	GO:0005515	protein binding	IPI	J:200373
Molecular Function	GO:0005515	protein binding	IPI	J:200373
Molecular Function	GO:0005515	protein binding	IPI	J:88736
Molecular Function	GO:0005515	protein binding	IPI	J:142596
Molecular Function	GO:0005515	protein binding	IPI	J:108459
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	TAS	J:73970
Molecular Function	GO:0017166	vinculin binding	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0031252	cell leading edge	IDA	J:142596
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:72247
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	IDA	J:214295
Cellular Component	GO:0005925	focal adhesion	IDA	J:80557
Cellular Component	GO:0005925	focal adhesion	IDA	J:98248
Cellular Component	GO:0005925	focal adhesion	IDA	J:62182
Cellular Component	GO:0005925	focal adhesion	IDA	J:108459
Cellular Component	GO:0005925	focal adhesion	IDA	J:86622
Cellular Component	GO:0005925	focal adhesion	IDA	J:217307
Cellular Component	GO:0005925	focal adhesion	IDA	J:216883
Cellular Component	GO:0005925	focal adhesion	IDA	J:99658
Cellular Component	GO:0005925	focal adhesion	IDA	J:142596
Cellular Component	GO:0005925	focal adhesion	TAS	J:73970
Cellular Component	GO:0005925	focal adhesion	TAS	J:76166
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	IDA	J:86622
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0001725	stress fiber	ISO	J:164563
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IDA	J:86622
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IEA	J:72247
Biological Process	GO:0007010	cytoskeleton organization	IMP	J:73970
Biological Process	GO:0043542	endothelial cell migration	ISO	J:164563
Biological Process	GO:0043542	endothelial cell migration	IBA	J:265628
Biological Process	GO:0048041	focal adhesion assembly	IDA	J:86622
Biological Process	GO:0060396	growth hormone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	IMP	J:73970
Biological Process	GO:0007229	integrin-mediated signaling pathway	TAS	J:76166
Biological Process	GO:0030032	lamellipodium assembly	IDA	J:86622
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:93907
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:214295
Biological Process	GO:0045860	positive regulation of protein kinase activity	IMP	J:199658
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	IMP	J:199658
Biological Process	GO:1901652	response to peptide	ISO	J:155856
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	IBA	J:265628
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	IMP	J:199658
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:213085
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628