GO Annotations Graph

• Symbol: Nfe2l2
• Name: nuclear factor, erythroid derived 2, like 2
• ID: MGI:108420

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:85958
Molecular Function	GO:0003677	DNA binding	IDA	J:79339
Molecular Function	GO:0003677	DNA binding	IDA	J:99071
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:53336
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:41943
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:79339
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:85958
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:235748
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:135362
Molecular Function	GO:0005515	protein binding	IPI	J:41943
Molecular Function	GO:0005515	protein binding	IPI	J:292826
Molecular Function	GO:0005515	protein binding	IPI	J:222136
Molecular Function	GO:0005515	protein binding	IPI	J:279942
Molecular Function	GO:0005515	protein binding	IPI	J:114001
Molecular Function	GO:0005515	protein binding	IPI	J:85958
Molecular Function	GO:0005515	protein binding	IPI	J:219149
Molecular Function	GO:0005515	protein binding	IPI	J:85958
Molecular Function	GO:0005515	protein binding	IPI	J:99071
Molecular Function	GO:0005515	protein binding	IPI	J:78907
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:53336
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:41943
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:41943
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:155856
Molecular Function	GO:0008134	transcription factor binding	IPI	J:241128
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:166919
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:166919
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:135362
Cellular Component	GO:0005737	cytoplasm	IDA	J:241128
Cellular Component	GO:0005737	cytoplasm	IDA	J:218003
Cellular Component	GO:0005737	cytoplasm	IDA	J:279946
Cellular Component	GO:0005737	cytoplasm	IPI	J:85958
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:196217
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8932375
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:218003
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:241128
Cellular Component	GO:0005634	nucleus	IDA	J:196217
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:85958
Cellular Component	GO:0005634	nucleus	IDA	J:99071
Cellular Component	GO:0005634	nucleus	IDA	J:89567
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032993	protein-DNA complex	IDA	J:85958
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	TAS	J:218003
Biological Process	GO:0046223	aflatoxin catabolic process	ISO	J:155856
Biological Process	GO:0045454	cell redox homeostasis	ISO	J:164563
Biological Process	GO:0045454	cell redox homeostasis	ISO	J:155856
Biological Process	GO:0045454	cell redox homeostasis	IMP	J:218003
Biological Process	GO:1904385	cellular response to angiotensin	ISO	J:155856
Biological Process	GO:0071280	cellular response to copper ion	IMP	J:212052
Biological Process	GO:0071498	cellular response to fluid shear stress	ISO	J:164563
Biological Process	GO:0042149	cellular response to glucose starvation	IMP	J:218003
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:0071499	cellular response to laminar fluid shear stress	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:166919
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:41943
Biological Process	GO:0034599	cellular response to oxidative stress	IBA	J:265628
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:168404
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IMP	J:219149
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:85958
Biological Process	GO:0006954	inflammatory response	IMP	J:219149
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:1902037	negative regulation of hematopoietic stem cell differentiation	IMP	J:195199
Biological Process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	ISO	J:164563
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0036499	PERK-mediated unfolded protein response	IDA	J:85958
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0030194	positive regulation of blood coagulation	IMP	J:166919
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IGI	J:89567
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:85958
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:99071
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:218003
Biological Process	GO:0046326	positive regulation of glucose import	IDA	J:219261
Biological Process	GO:1903788	positive regulation of glutathione biosynthetic process	IMP	J:218003
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	IMP	J:166919
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:53336
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:218003
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:242475
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:166919
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:169897
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:212052
Biological Process	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	ISO	J:164563
Biological Process	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	ISO	J:164563
Biological Process	GO:0010499	proteasomal ubiquitin-independent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:1900407	regulation of cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:79339
Biological Process	GO:0045995	regulation of embryonic development	IGI	J:89567
Biological Process	GO:0045088	regulation of innate immune response	IMP	J:107804
Biological Process	GO:2000121	regulation of removal of superoxide radicals	IMP	J:166919
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IMP	J:218003
Biological Process	GO:0010033	response to organic substance	IDA	J:261637