GO Annotations Graph

• Symbol: Fzd8
• Name: frizzled class receptor 8
• ID: MGI:108460

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0030165	PDZ domain binding	IPI	J:114051
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:166033
Molecular Function	GO:0005515	protein binding	IPI	J:245356
Molecular Function	GO:0005515	protein binding	IPI	J:114051
Molecular Function	GO:0005515	protein binding	IPI	J:326900
Molecular Function	GO:0005515	protein binding	IPI	J:204648
Molecular Function	GO:0005515	protein binding	IPI	J:164786
Molecular Function	GO:0005515	protein binding	IPI	J:184507
Molecular Function	GO:0005515	protein binding	IPI	J:137648
Molecular Function	GO:0005515	protein binding	IPI	J:229368
Molecular Function	GO:0005515	protein binding	IPI	J:113117
Molecular Function	GO:0005515	protein binding	IPI	J:93897
Molecular Function	GO:0005515	protein binding	IPI	J:113117
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:166033
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0042813	Wnt receptor activity	ISO	J:164563
Molecular Function	GO:0042813	Wnt receptor activity	IBA	J:265628
Molecular Function	GO:0042813	Wnt receptor activity	IPI	J:93897
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:228413
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:227398
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:229368
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:228413
Molecular Function	GO:0017147	Wnt-protein binding	IBA	J:265628
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:93897
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-NUL-1458871
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	EXP	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0005886	plasma membrane	IDA	J:107732
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-3858478
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-517516
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:1990851	Wnt-Frizzled-LRP5/6 complex	IPI	J:166033
Cellular Component	GO:1990851	Wnt-Frizzled-LRP5/6 complex	IPI	J:204648
Cellular Component	GO:1990851	Wnt-Frizzled-LRP5/6 complex	IDA	J:228413
Biological Process	GO:0001525	angiogenesis	IDA	J:143865
Biological Process	GO:0060070	canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:106895
Biological Process	GO:0060070	canonical Wnt signaling pathway	IDA	J:113117
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:67003
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:90938
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:91019
Biological Process	GO:0007166	cell surface receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IDA	J:163736
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:91019
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0033077	T cell differentiation in thymus	IMP	J:67003
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:227398
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:143865