GO Annotations Graph

• Symbol: Hrh2
• Name: histamine receptor H2
• ID: MGI:108482

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IBA	J:265628
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0004969	histamine receptor activity	ISO	J:155856
Molecular Function	GO:0030594	neurotransmitter receptor activity	IBA	J:265628
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0048565	digestive tract development	IMP	J:102139
Biological Process	GO:0048565	digestive tract development	IMP	J:62871
Biological Process	GO:0003382	epithelial cell morphogenesis	IMP	J:62871
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	J:265628
Biological Process	GO:0001696	gastric acid secretion	IGI	J:102139
Biological Process	GO:0001698	gastrin-induced gastric acid secretion	IMP	J:102139
Biological Process	GO:0001698	gastrin-induced gastric acid secretion	IMP	J:62871
Biological Process	GO:0048732	gland development	IMP	J:102139
Biological Process	GO:0001697	histamine-induced gastric acid secretion	IMP	J:62871
Biological Process	GO:0001697	histamine-induced gastric acid secretion	IMP	J:102139
Biological Process	GO:0007613	memory	IMP	J:119930
Biological Process	GO:1900139	negative regulation of arachidonic acid secretion	ISO	J:155856
Biological Process	GO:0045907	positive regulation of vasoconstriction	IEA	J:72247
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:119930
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:1901998	toxin transport	IMP	J:197389
Biological Process	GO:0008542	visual learning	IMP	J:119930