GO Annotations Graph

• Symbol: Hnf4a
• Name: hepatic nuclear factor 4, alpha
• ID: MGI:109128

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050544	arachidonic acid binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	IDA	J:188795
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:28121
Molecular Function	GO:0003677	DNA binding	IDA	J:94267
Molecular Function	GO:0003677	DNA binding	IDA	J:91695
Molecular Function	GO:0003677	DNA binding	IDA	J:111670
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:249196
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:97364
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:106993
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:28121
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:64004
Molecular Function	GO:0005504	fatty acid binding	ISO	J:155856
Molecular Function	GO:0005504	fatty acid binding	ISO	J:164563
Molecular Function	GO:0000062	fatty-acyl-CoA binding	ISO	J:155856
Molecular Function	GO:0036042	long-chain fatty acyl-CoA binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004879	nuclear receptor activity	IBA	J:265628
Molecular Function	GO:0016290	palmitoyl-CoA hydrolase activity	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:156994
Molecular Function	GO:0005515	protein binding	IPI	J:244975
Molecular Function	GO:0005515	protein binding	IPI	J:125929
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:188369
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:140378
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:16244
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0070540	stearic acid binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:97364
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:155856
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0000785	chromatin	IC	J:249196
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-186663
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:28121
Cellular Component	GO:0005634	nucleus	IDA	J:114400
Cellular Component	GO:0005634	nucleus	IDA	J:16244
Cellular Component	GO:0005634	nucleus	IDA	J:44977
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:97579
Cellular Component	GO:0005634	nucleus	IDA	J:106933
Cellular Component	GO:0005634	nucleus	IDA	J:45483
Biological Process	GO:0006637	acyl-CoA metabolic process	ISO	J:155856
Biological Process	GO:0048856	anatomical structure development	IBA	J:265628
Biological Process	GO:0007596	blood coagulation	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	ISO	J:155856
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0045216	cell-cell junction organization	ISO	J:155856
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:67396
Biological Process	GO:0007164	establishment of tissue polarity	ISO	J:155856
Biological Process	GO:0042593	glucose homeostasis	IMP	J:97364
Biological Process	GO:0070365	hepatocyte differentiation	IEA	J:72247
Biological Process	GO:0055088	lipid homeostasis	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IMP	J:106993
Biological Process	GO:1902569	negative regulation of activation of Janus kinase activity	ISO	J:155856
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045930	negative regulation of mitotic cell cycle	ISO	J:155856
Biological Process	GO:0042308	negative regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	ISO	J:155856
Biological Process	GO:0006591	ornithine metabolic process	ISO	J:164563
Biological Process	GO:0055091	phospholipid homeostasis	IMP	J:67396
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:271712
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:45483
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:249196
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:44977
Biological Process	GO:0045723	positive regulation of fatty acid biosynthetic process	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0045722	positive regulation of gluconeogenesis	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:67396
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:97364
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:106933
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:125929
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:108479
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:125929
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:94267
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:64004
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:28121
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:125929
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:125929
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:283180
Biological Process	GO:0042752	regulation of circadian rhythm	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:38391
Biological Process	GO:0010470	regulation of gastrulation	IMP	J:21129
Biological Process	GO:0050796	regulation of insulin secretion	IMP	J:97364
Biological Process	GO:0019216	regulation of lipid metabolic process	ISO	J:164563
Biological Process	GO:0032534	regulation of microvillus assembly	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:188369
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:188369
Biological Process	GO:0009749	response to glucose	IMP	J:97364
Biological Process	GO:0009749	response to glucose	ISO	J:155856
Biological Process	GO:0035983	response to trichostatin A	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0007548	sex differentiation	IMP	J:129617
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	IDA	J:155850
Biological Process	GO:0060395	SMAD protein signal transduction	IDA	J:45399
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:64004
Biological Process	GO:0070328	triglyceride homeostasis	IMP	J:67396
Biological Process	GO:0003323	type B pancreatic cell development	IEA	J:72247
Biological Process	GO:0006805	xenobiotic metabolic process	ISO	J:164563