GO Annotations Graph

• Symbol: Isl2
• Name: insulin related protein 2 (islet 2)
• ID: MGI:109156

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:239195
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:218609
Biological Process	GO:0007409	axonogenesis	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:89755
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:89755
Biological Process	GO:0030182	neuron differentiation	IMP	J:89755
Biological Process	GO:0030182	neuron differentiation	IGI	J:89755
Biological Process	GO:0048663	neuron fate commitment	IGI	J:89755
Biological Process	GO:0048663	neuron fate commitment	IMP	J:89755
Biological Process	GO:0048665	neuron fate specification	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0031290	retinal ganglion cell axon guidance	IMP	J:94630
Biological Process	GO:0021520	spinal cord motor neuron cell fate specification	IGI	J:152175
Biological Process	GO:0021524	visceral motor neuron differentiation	IGI	J:89755
Biological Process	GO:0021524	visceral motor neuron differentiation	IMP	J:89755