GO Annotations Graph

• Symbol: Hfe
• Name: homeostatic iron regulator
• ID: MGI:109191

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030881	beta-2-microglobulin binding	ISO	J:164563
Molecular Function	GO:0039706	co-receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:1990459	transferrin receptor binding	ISO	J:164563
Molecular Function	GO:1990459	transferrin receptor binding	IPI	J:117182
Molecular Function	GO:1990459	transferrin receptor binding	IBA	J:265628
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0045177	apical part of cell	ISO	J:164563
Cellular Component	GO:0045178	basal part of cell	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:1990712	HFE-transferrin receptor complex	IDA	J:117182
Cellular Component	GO:1990712	HFE-transferrin receptor complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0055037	recycling endosome	ISO	J:164563
Cellular Component	GO:1990357	terminal web	ISO	J:155856
Biological Process	GO:0002486	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA	J:265628
Biological Process	GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA	J:265628
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0071281	cellular response to iron ion	ISO	J:164563
Biological Process	GO:0042446	hormone biosynthetic process	IMP	J:118862
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0098711	iron ion import across plasma membrane	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	ISO	J:164563
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:53581
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:118862
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:168510
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:53581
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:90494
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:193218
Biological Process	GO:1904283	negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I	ISO	J:164563
Biological Process	GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation	ISO	J:164563
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IC	J:214454
Biological Process	GO:1900121	negative regulation of receptor binding	ISO	J:164563
Biological Process	GO:2000272	negative regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0002626	negative regulation of T cell antigen processing and presentation	IEA	J:72247
Biological Process	GO:0002725	negative regulation of T cell cytokine production	ISO	J:164563
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	IC	J:214454
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:1904434	positive regulation of ferrous iron binding	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:214454
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0090277	positive regulation of peptide hormone secretion	ISO	J:164563
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:1900122	positive regulation of receptor binding	ISO	J:164563
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:2000273	positive regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	IBA	J:265628
Biological Process	GO:1904437	positive regulation of transferrin receptor binding	ISO	J:164563
Biological Process	GO:0034756	regulation of iron ion transport	ISO	J:164563
Biological Process	GO:0034756	regulation of iron ion transport	IBA	J:265628
Biological Process	GO:2000008	regulation of protein localization to cell surface	ISO	J:164563
Biological Process	GO:0010039	response to iron ion	ISO	J:164563
Biological Process	GO:1990641	response to iron ion starvation	IBA	J:265628