GO Annotations Graph

• Symbol: Tradd
• Name: TNFRSF1A-associated via death domain
• ID: MGI:109200

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070513	death domain binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:108710
Molecular Function	GO:0005515	protein binding	IPI	J:281201
Molecular Function	GO:0005515	protein binding	IPI	J:228302
Molecular Function	GO:0005515	protein binding	IPI	J:138824
Molecular Function	GO:0005515	protein binding	IPI	J:151999
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	ISO	J:164563
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IBA	J:265628
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:108710
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0002947	tumor necrosis factor receptor superfamily complex	ISO	J:164563
Cellular Component	GO:0002947	tumor necrosis factor receptor superfamily complex	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	RCA	J:84168
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IGI	J:202809
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IGI	J:202809
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0051798	positive regulation of hair follicle development	IMP	J:108710
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:280922
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:280922
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	RCA	J:84168
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ISO	J:164563