GO Annotations Graph

• Symbol: Itpkb
• Name: inositol 1,4,5-trisphosphate 3-kinase B
• ID: MGI:109235

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051765	inositol tetrakisphosphate kinase activity	IBA	J:265628
Molecular Function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	ISO	J:164563
Molecular Function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	IBA	J:265628
Molecular Function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	IDA	J:86257
Molecular Function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	IMP	J:89286
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:92854
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:92854
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:92854
Biological Process	GO:0007166	cell surface receptor signaling pathway	IMP	J:89286
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:164563
Biological Process	GO:0035726	common myeloid progenitor cell proliferation	IMP	J:133360
Biological Process	GO:0032958	inositol phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0032957	inositol trisphosphate metabolic process	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	IMP	J:89286
Biological Process	GO:0002262	myeloid cell homeostasis	IMP	J:133360
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	IMP	J:133360
Biological Process	GO:0033030	negative regulation of neutrophil apoptotic process	IMP	J:133360
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	ISO	J:164563
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	IMP	J:89286
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	IMP	J:89286
Biological Process	GO:0045059	positive thymic T cell selection	IMP	J:89286
Biological Process	GO:0001932	regulation of protein phosphorylation	IMP	J:133360
Biological Process	GO:0030217	T cell differentiation	IMP	J:86257
Biological Process	GO:0045061	thymic T cell selection	IMP	J:86257