GO Annotations Graph

• Symbol: Ddit3
• Name: DNA-damage inducible transcript 3
• ID: MGI:109247

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008140	cAMP response element binding protein binding	ISO	J:164563
Molecular Function	GO:0008140	cAMP response element binding protein binding	IDA	J:198492
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IDA	J:95320
Molecular Function	GO:0003677	DNA binding	ISO	J:73065
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:198492
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:95320
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0043522	leucine zipper domain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:198492
Molecular Function	GO:0005515	protein binding	IPI	J:190264
Molecular Function	GO:0005515	protein binding	IPI	J:113873
Molecular Function	GO:0046982	protein heterodimerization activity	IDA	J:198492
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:155856
Molecular Function	GO:0046982	protein heterodimerization activity	IPI	J:38292
Molecular Function	GO:0046982	protein heterodimerization activity	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:218008
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:38292
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:95320
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IBA	J:265628
Molecular Function	GO:0140416	transcription regulator inhibitor activity	IDA	J:38292
Cellular Component	GO:1990622	CHOP-ATF3 complex	ISO	J:164563
Cellular Component	GO:1990622	CHOP-ATF3 complex	IBA	J:265628
Cellular Component	GO:1990617	CHOP-ATF4 complex	ISO	J:164563
Cellular Component	GO:1990617	CHOP-ATF4 complex	IBA	J:265628
Cellular Component	GO:0036488	CHOP-C/EBP complex	ISO	J:155856
Cellular Component	GO:0036488	CHOP-C/EBP complex	IPI	J:38292
Cellular Component	GO:0036488	CHOP-C/EBP complex	ISO	J:164563
Cellular Component	GO:0036488	CHOP-C/EBP complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:38292
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005770	late endosome	IDA	J:192731
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9644330
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9653747
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9653771
Cellular Component	GO:0005634	nucleus	IDA	J:38292
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:233583
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:190264
Cellular Component	GO:0005634	nucleus	IDA	J:124910
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	NAS	J:320139
Cellular Component	GO:0005634	nucleus	IDA	J:51759
Cellular Component	GO:0005634	nucleus	IC	J:95320
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IPI	J:218008
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Biological Process	GO:0009948	anterior/posterior axis specification	IDA	J:163135
Biological Process	GO:0006915	apoptotic process	IMP	J:190262
Biological Process	GO:0060840	artery development	IMP	J:267161
Biological Process	GO:0001955	blood vessel maturation	IMP	J:190262
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0045454	cell redox homeostasis	ISO	J:73065
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:198492
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IMP	J:95320
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IMP	J:268046
Biological Process	GO:0006983	ER overload response	ISO	J:155856
Biological Process	GO:0006983	ER overload response	IBA	J:265628
Biological Process	GO:0006983	ER overload response	IMP	J:74700
Biological Process	GO:0072655	establishment of protein localization to mitochondrion	IDA	J:233583
Biological Process	GO:0010467	gene expression	IGI	J:267161
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:52729
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	J:198492
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:167725
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA	J:265628
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:74700
Biological Process	GO:1990442	intrinsic apoptotic signaling pathway in response to nitrosative stress	IDA	J:233583
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:163135
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:249899
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	ISO	J:164563
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	ISO	J:155856
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	IBA	J:265628
Biological Process	GO:2000016	negative regulation of determination of dorsal identity	IDA	J:163135
Biological Process	GO:2000016	negative regulation of determination of dorsal identity	ISO	J:164563
Biological Process	GO:0043392	negative regulation of DNA binding	IGI	J:38292
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:190264
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:153833
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IGI	J:204800
Biological Process	GO:0032700	negative regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0032713	negative regulation of interleukin-4 production	ISO	J:164563
Biological Process	GO:0045662	negative regulation of myoblast differentiation	IMP	J:190264
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:38292
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:163135
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0032689	negative regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0034263	positive regulation of autophagy in response to ER overload	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA	J:218008
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:167725
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	IMP	J:167725
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	IMP	J:219626
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:218008
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:218008
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	NAS	J:95320
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IMP	J:95320
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ISO	J:155856
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IBA	J:265628
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0010506	regulation of autophagy	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:189996
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:153833
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:95320
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:153833
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:153833
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:167725
Biological Process	GO:0036119	response to platelet-derived growth factor	IMP	J:267161
Biological Process	GO:0042594	response to starvation	IDA	J:190264
Biological Process	GO:0006986	response to unfolded protein	ISO	J:164563
Biological Process	GO:0009611	response to wounding	IMP	J:267161
Biological Process	GO:0007605	sensory perception of sound	IGI	J:268046
Biological Process	GO:1904738	vascular associated smooth muscle cell migration	IMP	J:267161
Biological Process	GO:1990874	vascular associated smooth muscle cell proliferation	IMP	J:267161
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000