GO Annotations Graph

• Symbol: Pdcd6
• Name: programmed cell death 6
• ID: MGI:109283

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	IMP	J:127172
Molecular Function	GO:0048306	calcium-dependent protein binding	IPI	J:127172
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:240322
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:201254
Molecular Function	GO:0005515	protein binding	IPI	J:177167
Molecular Function	GO:0005515	protein binding	IPI	J:161035
Molecular Function	GO:0005515	protein binding	IPI	J:87334
Molecular Function	GO:0005515	protein binding	IPI	J:87334
Molecular Function	GO:0046983	protein dimerization activity	IPI	J:53664
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:53664
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:240322
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0043495	protein-membrane adaptor activity	ISO	J:164563
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	ISO	J:164563
Cellular Component	GO:0030127	COPII vesicle coat	ISO	J:164563
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:127172
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0070971	endoplasmic reticulum exit site	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:87334
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IDA	J:33763
Biological Process	GO:0034605	cellular response to heat	ISO	J:164563
Biological Process	GO:0048208	COPII vesicle coating	ISO	J:164563
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	ISO	J:164563
Biological Process	GO:0006886	intracellular protein transport	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0032007	negative regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0014032	neural crest cell development	ISO	J:164563
Biological Process	GO:0014029	neural crest formation	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:1902527	positive regulation of protein monoubiquitination	ISO	J:164563
Biological Process	GO:0051592	response to calcium ion	IDA	J:127172
Biological Process	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway	ISO	J:164563